HiLo: Multicentre randomised phase III clinical trial of high versus low dose radioiodine, with or without recombinant human thyroid stimulating hormone (rhTSH), for remnant ablation following surgery for differentiated thyroid cancer The main objectives of the trial are: (i) to determine whether a low dose of radioactive iodine (1.1 GBq) is as effective as the commonly used high dose (3.7GBq) in ablating any remaining thyroid ti...

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Investigation of Zibotentan for kidney disease in scleroderma The main objectives for this study is to see how safe Zibotentan is in patients with scleroderma and kidney damage and whether it has any effect on their kidney function

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FACT: laser-assisted versus standard ultrasound cataract surgery Background and study aims Cataracts are cloudy patches that develop in the lens of the eye and can cause blurred or misty vision. The only treatment that is proven to be effective for cataracts is sur...

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Standard open radical cystectomy (ORC) versus robotically assisted radical cystectomy (RARC) Lay summary under review with external organisation

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Investigating the feasibility of a group self-management program after stroke Background and study aims A stroke is a serious condition where the blood supply to a part of the brain is cut off, usually by a blood clot blocking an artery (ischaemic stroke) or a bleed (haemorrhag...

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Open label pilot study to treat women with chronic urinary retention or voiding dysfunction due to a primary disorder of sphincter relaxation (Fowler’s syndrome) with outpatient urethral sphincter injections of botulinum toxin A (BoNT-A) To investigate if urethral sphincter injections of botulinum toxin A can A) restore voiding in those with complete retention (the inability to pass any urine from the bladder normally). B) improve flo...

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Improving care of people with dementia in Black African and Caribbean groups Plain English summary under review.

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Respiratory illness in people living with HIV in the era of antiretroviral therapy Background and study aims The human immunodeficiency virus (HIV) is a type of virus known as a retrovirus. HIV attacks and weakens the immune system, making it more difficult for a sufferer to fight i...

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Optimising the cardiovascular system following liver transplantation surgery Background and study aims Cirrhosis is a serious complication of liver disease, which involves widespread scarring of the liver. The damage to the liver caused by cirrhosis means that eventually the l...

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A multi-centre exploratory study to evaluate the efficacy of the dopamine receptor agonist rotigotine in the treatment of hemispatial neglect and motor deficits following stroke To assess the effects of the drug rotigotine on the syndrome of hemispatial neglect and motor deficits following right-hemisphere stroke.

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