Kusajili – Centralise les essais cliniques mondiaux

The Role of the Cervical Spine in Carpal Tunnel Syndrome This randomized clinical trial will investigate changes in hand function, active cervical range of motion and pinch grip force after the application of physical therapy in women with carpal tunnel syndrome (CTS). The purpose of this study is to compare changes in function, cervical range of motion and pinch grip force induced after the application of a physical therapy program including manual therapies targeted to those areas related to the median nerve or after endoscopic surgery in women with CTS at medium and long-term follow-up. The hypothesis is that manual therapy is more effective for increasing cervical range of motion and pinch grip force, but similarly effective for improving function, than surgical treatment in women with CTS.

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Hypitat: Pregnancy-induced hypertension and pre-eclampsia after 36 weeks: induction of labour versus expectant monitoring. A comparison of maternal and neonatal outcome, maternal quality of life and costs Not provided at time of registration

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Safety of Coronectomy vs Excision of Wisdom Teeth The purpose of this study is to compare the surgical complications and neurosensory disturbance of coronectomy and conventional excision of wisdom teeth with roots in close proximity to inferior alveolar nerve. Hypothesis: Coronectomy of wisdom tooth can reduce the chance of injury to the inferior alveolar nerve in cases of radiographic proximity to the roots when compared with conventional method of surgical removal of wisdom teeth, and there is no difference in other surgical morbidities.

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Evaluation of a Training Model for the Proficient Use of the Belmont Rapid Infuser The Belmont Rapid Infuser is a device currently approved to replace larger volumes of necessary fluids such as blood in a fast and safe manner. The purpose of the study is to evaluate proficiency and the retention of knowledge of how to use the device based on current methods of training compared to revised training methods. Hypotheses: 1. The use of the traditional method of training is not effective, predicting less then half of staff will pass on the first attempt. 2. Restructured test with hands-on training as opposed to oral presentation only with a written test will result in a pass rate of > 80%. 3. Staff members who work in pairs will perform better than working alone when setting up the Belmont Rapid Infuser (BRI). 4. Retention at 3 months will be higher with the restructured training method than with the traditional training method.

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A Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception The primary objective of this study is to assess the efficacy of a levonorgestrel-releasing intrauterine system (LNG20) in nulliparous and parous females of child-bearing potential who request long-term, reversible contraception for up to 8 years.

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A repeat patch application study to determine what the body does to oxycodone in combination with tocopheryl phosphate mix, when delivered through the skin using different methods of repeat application

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Umbilical cord serum therapy in acute ocular chemical burns Not provided at time of registration

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An integrated review to evaluate dose response of umeclidinium (GSK573719) administered once or twice daily in Subjects with COPD The purpose of this study was to assess the total daily dose response of umeclidinium using pooled data from study AC4113073 and AC4115321 (excluding the site with Investigator ID of 040688) following once daily doses of umeclidinium (15.6, 31.25, 62.5, 125, 250, 500, and 1000mcg) and twice daily doses of umeclidinium (15.6, 31.25 62.5, 125, and 250mcg) compared with placebo in subjects with chronic obstructive pulmonary disease (COPD). Study AC4113073 was a multicentre, randomized, double-blind, double-dummy, placebo-controlled, three-way cross-over, incomplete block design study to evaluate the safety and efficacy of five doses of the long-acting muscarinic receptor antagonist umeclidinium (GSK573719) (62.5mcg, 125mcg, 250mcg, 500mcg, and 1000mcg) administered once-daily and three doses of umeclidinium (62.5mcg, 125mcg, and 250mcg) administered twice-daily compared with placebo over a 14 day treatment period in subjects with chronic obstructive pulmonary disease (COPD). Study AC4115321 was a multicenter, randomized, double-blind, placebo controlled, three way crossover, incomplete block study to evaluate the dose response of 4 doses of umeclidinium Inhalation Powder (15.6 mcg, 31.25 mcg, 62.5 mcg, and 125mcg) administered once daily over a 7 day treatment period in patients with COPD. Study AC4115321 also evaluated the safety and efficacy of the 4 doses of umeclidinium (15.6 mcg, 31.25 mcg, 62.5 mcg, and 125 mcg) administered once daily and 2 doses of umeclidinium (15.6 mcg and 31.25 mcg) administered twice daily compared with placebo over 7 days in subjects with COPD. An open label tiotropium (18mcg once-daily) group was included as an active control in both studies. This meta-analysis combined the two studies’ data together to evaluate the dose response of umeclidinium to better inform dose selection of umeclidinium.

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BioThrax® (Anthrax) Vaccine in Pregnancy Registry The purpose of this study is to determine if inadvertent receipt of the BioThrax vaccine during pregnancy is independently associated with adverse maternal, pregnancy, or infant health outcomes.

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A Study to Evaluate Pharmacokinetics and Potential Drug Interactions of a Fixed-dose Combination Tablet, HL-040XC, in Healthy Male Subjects The objective of this study is: To evaluate the pharmacokinetics and safety of an experimental combination tablet containing 20 mg atorvastatin and 50 mg losartan potassium when administered orally as a single dose to healthy male subjects, compared with the concomitant administration of 20 mg atorvastatin and 50 mg losartan potassium tablets.

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