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Control of periodontal inflammation, systemic inflammatory responses and cognitive decline in Alzheimer’'s disease

Mise à jour : Il y a 4 ans
Référence : ISRCTN34471493

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Background and study aims An important cause of inflammation (soreness and swelling), especially in older people, is gum disease. This can be treated by improving oral health – dentists can fix damaged teeth and dental hygienists can help to keep the gums healthy by cleaning and by providing advice. Some evidence suggests that inflammation is also important in Alzheimer's disease. This inflammation, both that caused by gum disease and that associated with Alzheimer's, can be measured in the blood. This study aims to find out if people with mild memory problems have inflammation that can be measured in their blood and whether improving gum health reduces that inflammation. If it does, then the next step, in another study, would be to see whether this affects the risk of getting Alzheimer's disease. Who can participate? People over the age of 65 who do not have dementia but do have some memory problems What does the study involve? People taking part in the study are randomly allocated to two groups: one receives an intensive dental treatment and the other receives usual care. They have an assessment of their memory and a blood and saliva test. Then they see a dentist and a dental hygienist. Some have regular treatment– fixing any major problems with their teeth and advice about how to keep the gums healthy. Others have more intensive dental hygiene. What are the possible benefits and risks of participating? The possible benefits are a good assessment of tooth and gum health for all participants followed by either normal standard of care or more intensive oral health treatment. The risks are nothing more than that of having a blood test. Where is the study run from? This is a study at King's Health Partners, –a group of hospitals including the Maudsley, King's College and Guys and St Thomas', London (UK) When is the study starting and how long is it expected to run for? November 2011 to November 2014 Who is funding the study? The Biomedical Research Centres at King's Health Partners (UK) Who is the main contact? Professor Simon Lovestone [email protected]

Critère d'inclusion

  • Periodontitis and disease progression in Alzheimer?s disease

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