Acute-On-Chronic Liver Failure Clinical Trials

132 clinical trials for Acute-On-Chronic Liver Failure across international registries, including 19 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients — RECRUITING · PHASE2
• Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy — RECRUITING · NA
• The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients — RECRUITING · NA
• COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device — RECRUITING · NA
• Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis — RECRUITING · NA
• Risk Factors Affecting MSC Efficacy in ACLF Patients — RECRUITING
• F573 for Injection for the Treatment of Liver Injury/Failure — RECRUITING · PHASE2
• Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs — RECRUITING
• CytOSorb TreatMent Of Critically Ill PatientS Registry — RECRUITING
• Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study — RECRUITING
• Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults — RECRUITING · PHASE1
• Continuous Renal Replacement Therapy Intensity in Hyperammonemia — RECRUITING · NA
• A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). — RECRUITING · PHASE2
• Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients — RECRUITING
• Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF — RECRUITING · NA
• Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF — RECRUITING
• Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure — RECRUITING
• Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure — RECRUITING · PHASE1
• Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease — RECRUITING
• Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure — NOT_YET_RECRUITING
• Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)® — TERMINATED · PHASE2
• Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients — COMPLETED · PHASE1
• Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% — TERMINATED · PHASE3
• Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF — NOT_YET_RECRUITING · NA
• EGEN-5784 Porcine Liver With the Metra® ELC Device — NOT_YET_RECRUITING · PHASE1
• Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF — COMPLETED · NA
• A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. — NOT_YET_RECRUITING · PHASE3
• Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy — COMPLETED · NA
• Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial) — NOT_YET_RECRUITING · NA
• Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial — NOT_YET_RECRUITING · NA
• miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial — COMPLETED · PHASE1
• Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. — NOT_YET_RECRUITING · NA
• PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure — ACTIVE_NOT_RECRUITING · PHASE1
• Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers — COMPLETED · PHASE1
• A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy — TERMINATED · PHASE2
• Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension — COMPLETED
• National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) — NOT_YET_RECRUITING · PHASE1
• National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial — NOT_YET_RECRUITING · PHASE2
• National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial — NOT_YET_RECRUITING · PHASE3
• A-TANGO Phase 2 Study — NOT_YET_RECRUITING · PHASE2
• Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients — COMPLETED · NA
• Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) — COMPLETED · PHASE1
• Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver Failure — ACTIVE_NOT_RECRUITING · PHASE1
• Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF — NOT_YET_RECRUITING · PHASE2
• Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections. — NOT_YET_RECRUITING · NA
• Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed — NOT_YET_RECRUITING · PHASE2
• Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial) — NOT_YET_RECRUITING · NA
• Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Liver Failure — COMPLETED
• Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock — OTHER · NA
• Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy — WITHDRAWN

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