Brain Metastases Clinical Trials

361 clinical trials for Brain Metastases across international registries, including 84 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets — RECRUITING
• A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer) — RECRUITING · PHASE2
• Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial) — RECRUITING · PHASE2
• Phase I Study of Fractionated Stereotactic Radiation Therapy — RECRUITING · NA
• Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases — RECRUITING · NA
• Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique — RECRUITING · PHASE2
• Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance — RECRUITING · PHASE2
• A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB) — RECRUITING · PHASE2
• Stereotactic Radiosurgery Dose Escalation for Brain Metastases — RECRUITING · PHASE1
• Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases — RECRUITING · PHASE2
• REMASTer: REcurrent Brain Metastases After SRS Trial — RECRUITING · NA
• Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies — RECRUITING · PHASE1
• Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases — RECRUITING · PHASE2
• A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain — RECRUITING · PHASE2
• Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases — RECRUITING · PHASE3
• Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy. — RECRUITING
• MeDex: No Perioperative Dexamethasone in Brain Metastases — RECRUITING · NA
• 18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery — RECRUITING · PHASE1
• Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases — RECRUITING · PHASE2
• ioMRI in the Surgery of Brain Metastases. — RECRUITING · NA
• Development of MRF for Characterization of Brain Tumors After Radiotherapy — RECRUITING · NA
• Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery — RECRUITING · PHASE1
• Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1 — RECRUITING · PHASE2
• NTS-WBRT in Brain Metastases — RECRUITING · PHASE2
• Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases — RECRUITING · PHASE2
• EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active — RECRUITING · PHASE2
• A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases — RECRUITING · PHASE2
• Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer. — RECRUITING · NA
• Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements — RECRUITING · PHASE1
• Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases — RECRUITING · PHASE3
• Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin — RECRUITING · NA
• Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients — RECRUITING · PHASE1
• Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers — RECRUITING
• The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? — RECRUITING · NA
• Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM) — RECRUITING · PHASE2
• Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment — RECRUITING
• Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer — RECRUITING · PHASE1
• REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis — RECRUITING · PHASE2
• Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases — RECRUITING · PHASE1
• Evaluation of the CONVIVO System — RECRUITING · NA
• Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT) — RECRUITING · PHASE2
• Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET) — RECRUITING · PHASE2
• Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI — RECRUITING · NA
• Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis — RECRUITING
• Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS) — RECRUITING · PHASE1
• Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases — RECRUITING · NA
• Frameless Stereotactic Radiosurgery for Intact Brain Metastases — RECRUITING · PHASE2
• Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma — RECRUITING · PHASE1
• 7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI) — RECRUITING
• Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis — RECRUITING · PHASE2

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