BRCA1 Mutation Clinical Trials

62 clinical trials for BRCA1 Mutation across international registries, including 14 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy — RECRUITING · NA
• Combination Therapy in Cancers With Mutations in DNA Repair Genes — RECRUITING · PHASE1
• Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors — RECRUITING · PHASE1
• A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies — RECRUITING · PHASE1
• SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells — RECRUITING · PHASE1
• Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer — RECRUITING · PHASE2
• BRCA Mutation Carriers' Platform a Multicenter Study — RECRUITING
• Liquid Biopsy Evaluation and Repository Development at Princess Margaret — RECRUITING
• An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results — RECRUITING · NA
• Genetic Education in BRCA Families — RECRUITING · NA
• Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer — RECRUITING · PHASE1
• Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer — RECRUITING · PHASE2
• Prostate Cancer Genetic Risk Evaluation and Screening Study — RECRUITING
• Registry of Subjects at Risk of Pancreatic Cancer — RECRUITING
• Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors — ACTIVE_NOT_RECRUITING · PHASE1
• Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations — ACTIVE_NOT_RECRUITING · PHASE2
• BRCA1/2 Flu Vaccine — ACTIVE_NOT_RECRUITING
• FaCT Trial (Facilitated Cascade Testing Trial) — ACTIVE_NOT_RECRUITING · NA
• BRCA Founder OutReach (BFOR) Study — ACTIVE_NOT_RECRUITING
• Evaluating Cascade Communication Methods — COMPLETED
• Radical Fimbriectomy for Young BRCA Mutation Carriers — ACTIVE_NOT_RECRUITING · NA
• Functional Analysis of BRCAness — TERMINATED · PHASE2
• HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer — COMPLETED · PHASE1
• LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients — ACTIVE_NOT_RECRUITING
• Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening — ACTIVE_NOT_RECRUITING · NA
• Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation — ACTIVE_NOT_RECRUITING · PHASE3
• Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy — SUSPENDED · NA
• Study to Evaluate TNG348 Alone and With a PARP Inhibitor in Patients With BRCA 1/2 Mutant or HRD+ Solid Tumors — TERMINATED · PHASE1
• Endocrine Disruptors and Life STILe in Breast Cancer Development — OTHER
• Chemo-free BRCA-targeted Neoadjuvant Strategy — WITHDRAWN · PHASE2
• Study to Evaluate Treatment Customized According to RAP80 and BRCA1 in Patients With Advanced Lung Carcinoma — TERMINATED · PHASE3
• BrUOG 390: Neoadjuvant Treatment With Talazoparib — TERMINATED · PHASE1
• The Genetic Education for Men Trial: Web-Based Education vs. Standard Care — COMPLETED · NA
• Surgical and Oncologic Outcomes After Robotic Nipple Sparing Mastectomy and Immediate Reconstruction — COMPLETED
• Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers — COMPLETED · PHASE4
• Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy — OTHER · NA
• Web-based Family History Tool — COMPLETED · NA
• Breast Cancer BRCA1 Carriers: a Pilot Study — WITHDRAWN
• Longitudinal Sample Collection to Investigate Adaptation and Evolution of Ovarian High-grade Serous Carcinoma — OTHER
• Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing — COMPLETED · NA
• A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer — COMPLETED
• Prospective Registry Trial for Single Port Robot-assisted Nipple Sparing Mastectomy (SPrNSM) — COMPLETED
• Dietary Intervention and BRCA Penetrance — COMPLETED · NA
• Depression and Body Image Distress Following Mastectomy With Reconstruction — COMPLETED
• Decision Support for BRCA Testing in Ethnically Diverse Women — COMPLETED · NA
• Recombinant Human Chorionic Gonadotropin in Preventing Breast Cancer in Premenopausal Women With BRCA1 Mutations — TERMINATED · NA
• Abbreviated Breast MRI for Second Breast Cancer Detection in Women With BRCA Mutation Testing — OTHER
• Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer — OTHER · PHASE2
• Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer — OTHER · PHASE2
• Health After eaRly Menopause Due to Oophorectomy — OTHER

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