Depressive Disorder, Major Clinical Trials

353 clinical trials for Depressive Disorder, Major across international registries, including 35 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS — RECRUITING · NA
• A Study of Brenipatide in Adult Participants With Major Depressive Disorder — RECRUITING · PHASE3
• A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder — RECRUITING · PHASE3
• Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms — RECRUITING · PHASE3
• A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder — RECRUITING · PHASE3
• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression — RECRUITING · PHASE2
• Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation — RECRUITING · PHASE2
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response — RECRUITING · PHASE1
• The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder — RECRUITING · PHASE2
• Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients — RECRUITING · PHASE3
• Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia — RECRUITING · NA
• NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits — RECRUITING · PHASE1
• bWell-D Pilot Randomized Controlled Trial — RECRUITING · NA
• Clinical Efficacy, Safety, and Applicability of Home-based Bright Light Therapy in Outpatient Adolescents With Major Depressive Disorder — RECRUITING · NA
• Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation — RECRUITING · NA
• Biomarkers of Depression and Treatment Response — RECRUITING · NA
• Psychiatric Genotype/Phenotype Project Repository — RECRUITING
• Dosing rTMS for Depression Post-SCI — RECRUITING · NA
• Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression — RECRUITING · NA
• Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness — RECRUITING · NA
• Prediction of Antidepressant Effects of Electroconvulsive Therapy — RECRUITING
• The Motor Activity - Subjective Energy (MASE) Project — RECRUITING · NA
• Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression — RECRUITING · NA
• Precision Care for Major Depressive Disorder — RECRUITING · PHASE4
• Optimal Electrical Stimulus During Electroconvulsive Therapy — RECRUITING · PHASE4
• Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab — RECRUITING · PHASE2
• The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Major Depressive Disorder — RECRUITING · NA
• Effectiveness of an Ecological Momentary Emotion Regulation Intervention — RECRUITING · NA
• Aerobic Versus Leisure Group for Adolescents With Depression — RECRUITING · NA
• Non-invasive Vagus Nerve Stimulation as a Tool to Modulate Stomach-Brain Coupling in Depression — RECRUITING · NA
• The Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression — RECRUITING · NA
• Precision Medicine in the Depression Treatment — RECRUITING
• InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI — RECRUITING · NA
• Peer-led Intervention for Individuals With Major Depression. — RECRUITING · NA
• Psychoeducational Intervention for Families With a Member Affected by Major Depression — RECRUITING · NA
• A Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Depression Who Take Anti-depressive Medication — COMPLETED · PHASE1
• A Study of Lumateperone Versus Placebo in Participants With Major Depressive Disorder — NOT_YET_RECRUITING · PHASE3
• A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder — ACTIVE_NOT_RECRUITING · PHASE2
• Psilocybin for Major Depressive Disorder (MDD) — ACTIVE_NOT_RECRUITING · PHASE3
• Individualized Functional Connectivity Targeting in aiTBS for Depression — COMPLETED · PHASE2
• A Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants With Major Depressive Disorder (MDD) — COMPLETED
• Brain Functional Connectivity Mechanism of Cognitive Flexibility Impairment and rTMS Intervention in Major Depressive Disorder — NOT_YET_RECRUITING · NA
• Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression — TERMINATED · NA
• Student Precarity and Psychiatry — NOT_YET_RECRUITING
• A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure — TERMINATED · PHASE3
• A Study to Test Different Doses of BI 1569912 in People With Depression — COMPLETED · PHASE2
• Personalized Sertraline Dosing in Patients With Depression — WITHDRAWN
• A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant — COMPLETED · PHASE3
• Cognitive Fitness for Depression in Older Adults — COMPLETED · NA
• Zelquistinel in the Treatment of Major Depressive Disorder — COMPLETED · PHASE2

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