Diseases [C] - Cardiovascular Diseases [C14] Clinical Trials

748 clinical trials for Diseases [C] - Cardiovascular Diseases [C14] across international registries, including 35 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• RECOMPENSE: Right vEntricular COMPENsation with SotatercEpt. A prospective single arm open label phase IV study to evaluate the effects of sotatercept on right ventricular function in pulmonary arterial hypertension — RECRUITING · PHASE4
• Effects of bempedoic acid/ezetimibe/high-intensity statin on plaque regression and stabilisation of coronary atherosclerosis among patients without cardiovascular events — RECRUITING · PHASE3
• Pharmacological optimization in prevention in Heart Failure: A Sex-gap? (PopS-HF Trial) — RECRUITING · PHASE4
• CLEOPATTRA: Effects of NNC6019-0001 versus placebo on cardiovascular outcomes in participants with transthyretin amyloid cardiomyopathy (ATTR-CM). — RECRUITING · PHASE3
• A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of REGN13335, an Anti-PDGF-B Monoclonal Antibody, in Adults with Pulmonary Arterial Hypertension — RECRUITING · PHASE2
• Early TRIPLE versus dual LIPID lowering treatment in peOple with atherosclerotic cardiovascular disease and hypercholesterolemia Undergoing elecTive revascularisation - The randomized, controlled, open-label, parallel group TRIPLE-LIPID-OUT trial — RECRUITING · PHASE4
• Randomised EValuation of Therapies for microvAscuLar Injury in STEACS – REVITALISE Study — RECRUITING · PHASE2
• Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE) — RECRUITING · PHASE4
• (21467) A Phase 3, single-arm, open-label extension study to evaluate the safety of finerenone in addition to standard of care, in pediatric heart failure patients, from birth to 18 years of age, with left ventricular systolic dysfunction (LVSD) — RECRUITING · PHASE3
• Efficacy and safety trial of intraperitoneal furosemide in patients on peritoneal dialysis — RECRUITING · PHASE4
• Phase II/III randomized controlled open-label trial to evaluate the efficacy and safety of personalized tissue engineered veins in patients with chronic venous insufficiency — RECRUITING · PHASE3
• Phase 3 Study to Evaluate the Efficacy and Safety of Zodasiran in Adolescent and Adult Subjects with Homozygous Familial Hypercholesterolemia (YOSEMITE) — RECRUITING · PHASE3
• (23026) A prospective, single-arm, Phase 4 study to evaluate the course of serum transthyretin (TTR) level with acoramidis in adult patients with variant or wild-type transthyretin amyloidosis with cardiomyopathy (ATTR-CM) previously treated with tafamidis. — RECRUITING · PHASE4
• The effect of beta-blockers on how you feel and recover after a heart attack when your heart is still pumping well — RECRUITING · PHASE4
• Two part (double-blind inclisiran versus placebo [Year 1] followed by open-label inclisiran [Year 2]) randomized multicenter study to evaluate safety, tolerability and efficacy of inclisiran in children (2 to less than 12 years) with homozygous familial hypercholesterolemia and elevated LDL-cholesterol (ORION-19) — RECRUITING · PHASE3
• Antiplatelet Secondary Prevention International Randomised study after INtracerebral haemorrhaGe - SM — RECRUITING · PHASE4
• COLchicine and non-enteric coated aspirin in the Cardiovascular Outcomes Trial of patients with Type 2 Diabetes (COLCOT-T2D) — RECRUITING · PHASE3
• Phase 1b Study of VERVE-201 in Patients with Refractory Hyperlipidemia — RECRUITING · PHASE1
• A Phase 1/2, Open-Label, Dose Finding Study to Investigate the Safety, Tolerability, and Efficacy of ALXN2350 Gene Therapy in Adult Participants with Symptomatic BAG3 Mutation-Associated Dilated Cardiomyopathy — RECRUITING · PHASE2
• A multicentric, randomized, double-blind, parallel, placebo-controlled phase III study to assess the safety and efficacy of sovateltide in patients with acute cerebral ischemic stroke. — RECRUITING · PHASE3
• Augmenting ischemia-induced vasculo- and angiogenesis after endovascular reperfusion with host-extracted, percutaneously introduced, leucocyte- and platelet-rich fibrin in patients with critical limb ischemia — RECRUITING · PHASE1
• A Pilot Study on the Use of Gadopiclenol for Enhanced Cardiac MRI in Children with Congenital Heart Conditions: A self-controlled, non-randomised, open-label study to compare the image quality and diagnostic performance of gadopiclenol versus gadoterate meglumine — RECRUITING · PHASE3
• Withdrawal of neurohormonal therapy in patients with non-ischemic cardiomyopathy, no late gadolinium enhancement, and negative genetic testing, who have exhibited super-response to cardiac resynchronization therapy. DRUGLESS-CRT clinical trial. — RECRUITING · PHASE3
• AMUNDSEN - Acute Myocardial infarction Upbound to percutaneous coronary intervention, immediately (STEMI) or in the Next three Days (NSTEMI), and randomized to Subcutaneous Evolocumab or Normal strategies to reach guidelines LDL objectives in the real-world - The AMUNDSEN-real trial- — RECRUITING · PHASE4
• A three-way cross-over phase IIa trial using L-citrulline and folic acid in combination with vericiguat and tadalafil in patients with treatment-resistant hypertension — RECRUITING · PHASE2
• Clairance de la morPHinE et filtration glomérulaire chez le Drepanocytaire en crise en REAnimation_PHEDREA — RECRUITING · PHASE4
• The QUEEN-IVF trial: Quinidine versus verapamil in short-coupled idiopathic ventricular fibrillation: An open-label, randomized crossover pilot trial — RECRUITING · PHASE2
• EvaluaTion of Clinical and laboratory outcomes of Rivaroxaban in short Bowel syndrome patients dEpending on Long term parenteral nutrition: a prospective cohort study (TINCRBEL study) — RECRUITING · PHASE4
• TENECTEPLASE IN CENTRAL RETINAL ARTERY OCCLUSION STUDY (TenCRAOS): A Prospective, randomised-controlled, double-dummy, double-blind phase 3 multi-centre trial of TNK 0.25 mg/kg + placebo vs. ASA + placebo (2 arms with 1:1 block randomisation) — RECRUITING · PHASE3
• CROSS-OVER ANALYSIS OF THE CONTROL OF RISK FACTORS AND ANTIAGGREGATION WITH POLIPILL (POLICROSS TRIAL) — RECRUITING · PHASE3
• Platelet inhibition versus direct oral anticoagulation in patients undergoing percutaneous closure of patent foramen ovale or atrial septal defect — RECRUITING · PHASE2
• Optimal drug therapy for the suppression of ventricular arrhythmias in Andersen-Tawil syndrome and multifocal ectopic Purkinje-related premature contractions: a series of N-of-1 trials — RECRUITING · PHASE4
• Prophylaxis of venous thromboembolic disease with LMWH (TINzaparin) in patients with metastatic colorectal cancer who start the first line of treatment. — RECRUITING · PHASE3
• VerifyNow to Optimise Platelet Inhibition in Coronary Acute Syndrome (VERONICA) — RECRUITING · PHASE3
• The role of meldonium and individualized physical activities in the treatment of patients with heart failure — RECRUITING · PHASE4
• A phase III, randomized, open-label, blinded endpoint, comparative trial of ferric derisomaltose versus no intravenous iron in iron-deficient subjects with symptomatic chronic heart failure — TERMINATED · PHASE3
• DISTINCT: inDividual, targeted thrombosIS prophylaxis versus the standard ‘one size fits all’ approach in patients undergoing Total hIp or total kNee replaCemenT: a national, multicenter, randomized, multi-arm, open-label trial — TERMINATED · PHASE4
• Thrombolysis with Tenecteplase for Acute Ischemic Stroke in Patients taking Direct Oral Anticoagulants – a multicentre randomised placebo-controlled clinical trial — TERMINATED · PHASE3
• A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with pelacarsen (TQJ230) on major cardiovascular events in patients with established cardiovascular disease — TERMINATED · PHASE3
• A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF) — NOT_YET_RECRUITING · PHASE2
• SGLT2 INHIBITION FOR CARDIOVASCULAR ENDPOINT REDUCTION IN HYPERTENSION — TERMINATED · PHASE3
• [22961] A placebo-controlled, parallel-group, double blind, randomized, multi-cohort Phase 2 study to investigate efficacy, safety, tolerability, pharmacodynamics and pharmacokinetics of BAY 3670549 in adult participants with atrial fibrillation. — NOT_YET_RECRUITING · PHASE2
• Spironolactone and SGLT2 inhibitor to Address Fontan circulatory failure and Enhance Resilience: The SAFER-Fontan trial — NOT_YET_RECRUITING · PHASE3
• A single arm, multicenter, open-label extension (OLE) trial to evaluate long-term safety and tolerability of pelacarsen (TQJ230) in participants who completed the parent Lp(a)HORIZON trial — TERMINATED · PHASE3
• A Phase 2b/3, Adaptive, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Danicamtiv in Participants with Symptomatic Genetic and Familial Dilated Cardiomyopathy (KINSHIP-DCM). — TERMINATED · PHASE3
• An Open-label Extension Study to Evaluate the Safety and Tolerability of Sotatercept (MK-7962) Administered Using a Weight-banded Approach in Participants With Pulmonary Arterial Hypertension (PAH) on Standard of Care. — TERMINATED · PHASE2
• A contrast medium sparing strategy using automated Carbon Dioxide Injection during PERIpheral vascular interventions for PREVENTion of Major Adverse Kidney Events (MAKE): the PeriPREVENT randomized controlled trial — TERMINATED · PHASE3
• Bioavailability Comparison of Finerenone 20 mg Tablets (Test vs. Comparator Product). — NOT_YET_RECRUITING · PHASE1
• A multicentre randomised study on percutaneous stellate ganglion block as first line treatment in patients with electrical storm: the STAR 2 study — NOT_YET_RECRUITING · PHASE3
• A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared with Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function — TERMINATED · PHASE3

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