Diseases [C] - Otorhinolaryngologic Diseases [C09] Clinical Trials

57 clinical trials for Diseases [C] - Otorhinolaryngologic Diseases [C09] across international registries, including 3 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• A Multicenter, Two-arm, Double-blind, Double dummy, Parallel-group Study for efficacy and safety evaluation of prolonged release formulation of Betahistine PR 48 mg once daily in comparison with conventional release formulation of Betahistine IR 24 mg, twice daily in treatment of adult patients with Menière's disease — RECRUITING · PHASE3
• ImmunotherApy for the Prevention of High-Risk Oral DIsorders malignanT transformation - APHRODITE trial — RECRUITING · PHASE2
• TINNITOX - Botulinum toxin A in tinnitus patients with concurrent bruxism and/or jaw muscle myalgia. A triple blind, randomized, placebo-controlled cross-over trial. — RECRUITING · PHASE3
• Evaluation of the efficacy, safety, and tolerability of lutetium-177-labeled PSMA ligand in patients with progression of adenoid cystic carcinoma originating from the salivary glands - an open, non-commercial clinical trial — NOT_YET_RECRUITING · PHASE2
• A phase 1 study of FluBHPVE6E7 immunotherapy in patients with HPV16-associated oropharyngeal squamous cell carcinoma — TERMINATED · PHASE1
• Nordic PREdnisolon for VEstibular NeuriTis Study – an investigator-driven, triple blind, placebo controlled randomized trial — NOT_YET_RECRUITING · PHASE3
• A Phase I/II, open-ended, adaptative, open label dose escalation and expansion clinical trial to evaluate the efficacy and safety of unilateral intracochlear injection of SENS-501 using an injection system in children with severe to profound hearing loss due to Otoferlin gene mutations — TERMINATED · PHASE2
• A prospective, randomised, multi-centre, double-blind, placebo-controlled Phase III trial to investigate the efficacy and safety of lozenges with benzydamine hydrochloride and dichlorobenzyl alcohol in the symptomatic treatment of patients suffering from acute pharyngitis — COMPLETED · PHASE3
• A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Lebrikizumab/LY3650150 in Participants with Chronic Rhinosinusitis with Nasal Polyps on Background Intranasal Corticosteroids — TERMINATED · PHASE3
• Tolerability and efficacy of treating locally advanced Resectable Oral Cancer with neoadjuvant INtratumoral anti-CTLA4 ImmunoTherapy combined with systemic anti-PD-1 (ROCinIT). — NOT_YET_RECRUITING · PHASE2
• Randomized, observer-blind, placebo-controlled, four Parallel Group, Clinical Trial for exploring the Efficacy and Tolerability of two different strengths ketotifen nasal spray (Ketotifen 0.025 mcg/ml and 0.050 mcg/ml) vs sodium cromoglicate nasal spray 2% in Patients with Rhinitis — NOT_YET_RECRUITING · PHASE2
• Evaluation of the Non-Inferiority of Topical Chloramphenicol Versus Topical Ciprofloxacin in the Resolution of Otorrhea in Adults With Chronic Suppurative Otitis Media (CSOM) – Protocol OMCOS — NOT_YET_RECRUITING · PHASE3
• A Phase II Randomized Clinical Trial Comparing Two Cycles Versus Four Cycles of Combination Therapy with Cetuximab, Avelumab, Cisplatin, and Docetaxel in Patients with Recurrent Metastatic Head and Neck Cancer - AVETUX-HN — TERMINATED · PHASE2
• Prevention of radiation-induced salivary gland damage by botulinum toxin application in patients with head and neck cancers — NOT_YET_RECRUITING · PHASE2
• Comparison between Ropivacain and Lidocain used as local anaesthesia regarding postoperative pain outcome after tonsillectomy — TERMINATED · PHASE4
• Comparing intraoperative indocyanine green fluorescence imaging with standard clinical assessment for flap perfusion in head and neck reconstruction: A randomised controlled Trial (VISION Trial) — NOT_YET_RECRUITING · PHASE4
• A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment with Tezepelumab (ESSENCE) — TERMINATED · PHASE3
• Neoadjuvant pembrolizumab in high-risk thyroid cancers (NEPENTHE) — TERMINATED · PHASE2
• A non-commercial, randomized, open-label clinical trial to evaluate the efficacy of 1.8-cineole compared to mupirocin in the treatment of chronic rhinitis caused by carriage of methicillin-resistant Staphylococcus aureus (NOSE) — OTHER · PHASE3
• Direct comparison of Tezepelumab and Dupilumab in CRSwNP in a real world setting — NOT_YET_RECRUITING · PHASE4
• PAROCAINE : Evaluation of the Clinical Tolerance of an Intra-Parotid Injection of Bupivacaine Combined with Dexamethasone After Parotidectomy for a Benign Tumor – Prospective Single-Center Cohort Study — TERMINATED · PHASE2
• INNOVATIVE TREATMENT OF SCARRED VOCAL FOLDS BY LOCAL INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STROMAL VASCULAR FRACTION: EFFICACY VERSUS PLACEBO — TERMINATED · PHASE2
• SERORL Effect of aspirin and folic acid for sudden sensorineural hearing loss — NOT_YET_RECRUITING · PHASE3
• Impact of Early Thyroid Hormone Replacement on Kidney Function and Health-Related Quality of Life in Patients at Risk of Postoperative Hypothyroidism after Hemithyroidectomy: A Randomised Controlled Trial — TERMINATED · PHASE4
• PANACEA : Effect of PrehAbilitation by NutritionAl supplementation with Cannabidiol on skeletal muscle mass and mitochondrial function in hEad and neck cAncer : a proof of concept controlled randomized trial — NOT_YET_RECRUITING · PHASE2
• C5541010 - A PHASE 2A, RANDOMIZED, DOUBLE BLIND, SPONSOR OPEN, PLACEBO CONTROLLED, PARALLEL GROUP, DOSE-RANGING STUDY OF PF 07976016 TO ASSESS SAFETY AND EFFICACY IN ADULT PARTICIPANTS WITH OBESITY — OTHER · PHASE2
• English title: Complete remission study Subtitle: Discontinuation of Mepolizumab or Dupilumab after at least 12 months without symptoms in patients with severe Chronic rhinosinusitis with polyps – a National Danish RCT study. — TERMINATED · PHASE4
• English Title: Tapering of biologics in CRSwNP Subtitle: Tapering of Mepolizumab or Dupilumab after 12 months of complete or partial disease control in patients with severe chronic rhinosinusitis with nasal polyposis – a national Danish RCT. — TERMINATED · PHASE4
• Phase II, Multi-Center, Randomized, Blinded Study Evaluating the Efficacy, Safety and Tolerability of a Single Intratympanic Dose of AC102 Compared to Oral Steroids for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss — OTHER · PHASE2
• A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Lebrikizumab/ LY3650150 in Adult Participants With Perennial Allergic Rhinitis — TERMINATED · PHASE3
• Open-label, randomized, two-period, two-treatment, two-sequence, crossover, balanced, study to assess the bioequivalence between the test product Betahistine dihydrochloride 24 mg tablets from Esperante Development BV and reference product Betaserc® 24 mg tablets. — OTHER · PHASE1
• A prospective, multi-centre, randomised, double-blind, placebo-controlled Phase III trial to investigate the efficacy and safety of lozenges with benzydamine hydrochloride and dichlorobenzyl alcohol in the symptomatic treatment of patients suffering from acute pharyngitis — OTHER · PHASE3
• Hyperbaric OXygen therapy for ACute Acoustic Trauma; HOXACAT — OTHER · PHASE3
• Repeated Mesenchymal Stem Cell Therapy for Radiation-Induced Hyposalivation and Xerostomia in Head and Neck Cancer Survivors — NOT_YET_RECRUITING · PHASE2
• Optimisation of treatment in patients with CRSwNP. An RCT of mepolizumab and surgical treatment with FESS and mepolizumab versus only mepolizumab over a 6- and 12-month follow-up — TERMINATED · PHASE3
• SOPAZITHRO : Evaluation of the Efficacy of 3-month Continuous Extended Treatment With Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults: a Multicentre Randomised Controlled Trial — TERMINATED · PHASE3
• Botulinum toxin injection in the upper esophageal sphincter for retrograde-cricopharyngeus dysfunction: a double blind, placebo-controlled trial. — TERMINATED · PHASE4
• BCS-ORL - Evaluation of the superficial cervical plexus block in oncological throat and neck surgery — TERMINATED · PHASE3
• Hyperbaric oxygen treatment added to standard care for acute idiopathic sudden sensorineural hearing loss - a multicentre randomized controlled trial — TERMINATED · PHASE3
• A Randomized, Multicentre, Seamless, Adaptive Phase I/II Study to Determine Safety and Efficacy of RhinoPHAGE-2A cocktail in Patients with Chronic Rhinosinusitis Associated with Staphylococcus aureus Infection — OTHER · PHASE2
• Effect of Tezepelumab on barrier function in severe asthmatic patients with and without comorbid chronic rhinosinusitis with nasal polyps – an exploratory study — TERMINATED · PHASE4
• Extracellular Vesicle-enriched Secretome Fraction (VSF1.01) for the Reduction of Cochlear Implant Surgery Related Trauma (ESCRT). An open-label monocentric phase I/IIa pilot study to investigate the safety of intracochlear application of VSF1.01 enriched with hUC-MSC-EVs in patients receiving cochlear implantation. — TERMINATED · PHASE2
• Neoadjuvant pembrolizumab plus chemotherapy in locally advanced sinonasal carcinoma (NeoPeSino) — TERMINATED · PHASE2
• A Phase IIa, Multicenter, Randomized, Controlled, Open label Study to Evaluate the Efficacy of SENS-401 to Prevent the Ototoxicity induced by Cisplatin in Adult Subjects with a Neoplastic Disease — OTHER · PHASE2
• Intracochlear Triamcinolone acetonide in sudden sensorineural hearing loss patients - a prospective observer blinded randomized study — TERMINATED · PHASE2
• RAPAMALYMPH - Evaluation of the Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations of Poor Prognosis — NOT_YET_RECRUITING · PHASE2
• Treatment of Warthin's tumor: schlerotherapy and its natural course — NOT_YET_RECRUITING · PHASE4
• Antimicrobial treatment of laryngeal leukoplakia — NOT_YET_RECRUITING · PHASE4
• Corticosteroid in treatment of acute laryngitis among vocal professionals — NOT_YET_RECRUITING · PHASE3
• Patient reported efficacy of intranasal lysine-aspirin in controlling NSAID-exacerbated respiratory disease. — OTHER · PHASE2

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