Diseases [C] - Pathological Conditions, Signs and Symptoms [C23] Clinical Trials

124 clinical trials for Diseases [C] - Pathological Conditions, Signs and Symptoms [C23] across international registries, including 7 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• LYSARI – LYmphocyte-Sparing And Radio-Immunotherapy in Head and neck carcinoma - A multicenter, randomised 2*2 factorial design comparing standard to reduced-target volume radiotherapy with or without all-trans retinoic acid (ATRA) in patients with lateralised oropharyngeal, laryngeal and hypopharyngeal squamous cell carcinoma. — RECRUITING · PHASE3
• A Phase 2, Multi-center, Randomized, Dose-Ranging, Placebo-Controlled, Double-blind Study of the Relaxin Agonist R2R01 in Patients at High Risk for Cardiac Surgery Associated - Acute Kidney Injury. — RECRUITING · PHASE2
• Efficacy and safety trial of intraperitoneal furosemide in patients on peritoneal dialysis — RECRUITING · PHASE4
• Double-T - Improving outcomes in high-risk 2nd line relapsed/refractory Large B-Cell Lymphoma patients eligible for CAR-T-cell therapy with a Glofitamab-based induction and consolidation concept — RECRUITING · PHASE2
• Interest of belatacept as a non-nephrotoxic immunosuppressive treatment in cardiac transplant patients at risk of chronic renal failure. — RECRUITING · PHASE2
• Clairance de la morPHinE et filtration glomérulaire chez le Drepanocytaire en crise en REAnimation_PHEDREA — RECRUITING · PHASE4
• Impact of Albumin on Renal function in critically ill patients with Septic Shock and a high risk of Acute Kidney Injury. A Randomized Controlled Trial. — RECRUITING · PHASE4
• Statin Intervention for Severe Early-Onset Placental Insufficiency: A Randomized Controlled Trial Assessing daily Administration as a Treatment Strategy (STATIN-PRE trial) — TERMINATED · PHASE3
• A Multicenter, Rollover Study to Evaluate the Long-Term Safety and Efficacy of Atacicept — TERMINATED · PHASE2
• A Phase 2 Study to Evaluate the Safety and Efficacy of Atacicept in Multiple Autoimmune Glomerular Diseases (PIONEER) — TERMINATED · PHASE2
• An Open-Label Phase IIa Trial Exploring the Safety, Tolerability, and Efficacy of the T Cell Engager OM336 for Desensitization of Kidney Transplant Candidates — NOT_YET_RECRUITING · PHASE2
• A phase 1/2a multicenter trial to evaluate the safety and immunogenicity of the CD40.Pan.CoV vaccine, adjuvanted or not, as a booster in adult participants — TERMINATED · PHASE1
• THE ROLE OF PANCREATIC STONE PROTEIN (PSP) AND PSP-GUIDED EARLY MEROPENEM TREATMENT TO MITIGATE SEPSIS RISK AT THE EMERGENCY DEPARTMENT: THE PROMISE DOUBLE BLIND, PHASE III, RANDOMIZED CONTROLLED CLINICAL TRIAL — NOT_YET_RECRUITING · PHASE3
• Whole body HER2 quantification with 89Zr-Trastuzumab PET/CT to asses Zr-trastuzumab accumulation in HER2-mutated and HER2-overexpressing metastatic non-small cell lung cancer — NOT_YET_RECRUITING · PHASE1
• BOOSTER – Multicenter, Open Label, Randomized Control Phase III Trial Comparing the Efficacy and Safety of Two Rituximab Regimens in Maintenance Therapy for Relapsing Nephrotic Syndrome Due to Podocytopathies in Adults. — TERMINATED · PHASE3
• A Phase 2/3, Open-label, Baseline-controlled, Multicenter, Long-term Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age with Neurogenic Detrusor Overactivity (NDO) on Clean Intermittent Catheterization (CIC) — TERMINATED · PHASE3
• A Phase 3, Multi-center, Randomized, Open-Label Clinical Study of Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy as First-Line Treatment in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma — TERMINATED · PHASE3
• Interventional, multicenter, open-label, randomized, non-comparative trial evaluating the safety, in terms of HBV virological control, of 2 antiviral treatment relief strategies, in patients co-infected with the HIV-1 and HBV viruses — TERMINATED · PHASE2
• S-ketamine for cortical spreading depolarisation in patients with severe acute brain injury (KETA-BID trial) — TERMINATED · PHASE4
• SETRAPED : A prospective, multicenter study evaluating the efficacy and tolerance of transmucosal midazolam for proportionate palliative sedation in children with refractory symptoms — NOT_YET_RECRUITING · PHASE2
• TIC-TAC-SAM « Comparison of two strategies of etoposide initiation in severe sporadic hemophagocytic lymphohistiocytosis in intensive care: a randomized trial » — NOT_YET_RECRUITING · PHASE3
• Obinutuzumab for systemic lupus erythematosus pure membranous nephropathy: a phase II trial (OBLUMEN) — NOT_YET_RECRUITING · PHASE2
• MucPreDex: Radiation-induced MUCositis PREvention using DEXpanthenol mouth rinse — TERMINATED · PHASE3
• Effect of Alpha-1 Antitrypsin Supplementation in Alcohol-Associated Hepatitis-A prospective Pilot Study — TERMINATED · PHASE2
• DASSOH - Systematic use of DDAVP to prevent serum sodium overcorrection in severe hyponatremia : a multicenter open-label randomized controlled trial — TERMINATED · PHASE3
• GYNET : A randomized, multicenter, open label, Phase I/II study to evaluate the safety (Phase I - safety run in), clinical and biological activity (Phase II) of a humanized monoclonal antibody targeting Netrin-1 (NP137) in combination with carboplatin plus paclitaxel and/or pembrolizumab in patients with locally advanced/metastatic endometrial carcinoma or cervix carcinoma progressing/relapsing after at least one prior systemic chemotherapy — TERMINATED · PHASE2
• A Phase 3, Multicenter, Open-label, Long-term, Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects with Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP) — TERMINATED · PHASE3
• PsyPal; Psilocybin Therapy for Psychological Distress in Palliative Patients — TERMINATED · PHASE2
• A Study Evaluating Monthly (Every 4 Weeks) Dosing of Atacicept in Patients with IgAN — TERMINATED · PHASE2
• A randomized phase III trial of short-course versus long-course pre-operative chemotherapy with mFOLFIRINOX or PAXG regimen for stage I-III pancreatic ductal adenocarcinoma (PDAC) — NOT_YET_RECRUITING · PHASE3
• A multicenter, multinational, pharmacokinetic, safety, and efficacy study with IV NEPA (fosnetupitant/palonosetron) for the prevention of chemotherapy-induced nausea and vomiting in pediatric cancer patients undergoing highly emetogenic chemotherapy (HEC). A 2-part study with Phase 2, open-label, randomized, single-dose IV NEPA vs fosaprepitant/ondansetron in single-day HEC and repeated-dose IV NEPA in multi-day HEC (Part I, single cycle) and with Phase 3, double-blind, randomized, repeated-dose — TERMINATED · PHASE3
• Short-term Pre-OPerative Durvalumab (MEDI 4736) in early small triple negative breast cancer patients (POP-Durva) — OTHER · PHASE2
• Randomised, Open-label, Phase III Study of AZD5335 Versus Mirvetuximab Soravtansine in FRα-high and AZD5335 Versus Investigator’s Choice Chemotherapy in FRα-low Expressing High-grade Platinum-resistant Epithelial Ovarian Cancer Patients (TREVI-OC-01) — TERMINATED · PHASE3
• A randomized controlled trial of Rikkunshito (TJ-43) in Functional Dyspepsia patients recruited from primary care. — TERMINATED · PHASE3
• A phase 2 clinical trial on neoadjuvant pembrolizumab in patients diagnosed with high-risk melanoma without clinical evidence of metastatic dissemination. — TERMINATED · PHASE2
• Effect of long-term carvedilol to prevent decompensation or death in patients with asymptomatic Child-Pugh A5 to B8 cirrhosis and clinically significant portal hypertension: a multicenter, double-blind, randomized controlled trial. — TERMINATED · PHASE4
• NEurotrophins MImetic compound for modulation of ischemia/reperfusion damage in Liver transplantation with Extended criteria Donors, a phase I/II explorative, open label, controlled, randomized study — NOT_YET_RECRUITING · PHASE2
• MOOD - MethOxyflurane analgesia in vasoOcclusive crises of sickle cell Disease — OTHER · PHASE3
• A Phase 2, Open-Label, Single-Arm, Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Sparsentan Treatment in Pediatric Subjects with Selected Proteinuric Glomerular Diseases (EPPIK) — TERMINATED · PHASE2
• Evaluation of the Pharmacokinetics of Subcutaneous Administration of Piperacillin/Tazobactam: An Open-Label, Multicentric, Non-Inferiority Randomized Clinical Trial (STUPITA01) — TERMINATED · PHASE2
• Evaluation of a Therapeutic Strategy to Shorten Hospital Stay in Complicated Pediatric Appendicitis: A Randomized, Parallel, Multicenter, Open-Label Clinical Trial — TERMINATED · PHASE4
• Safety and efficacy of a human albumin solution with restored structural profile in patients with decompensated cirrhosis — TERMINATED · PHASE2
• Changes in the wound microbiome and their impact on chronic wound healing under hyperbaric conditions — TERMINATED · PHASE4
• First in human clinical trial to evaluate the safety, tolerability and preliminary efficacy of the bispecific CD276xCD3 antibody CC-3 in patients with colorectal cancer — TERMINATED · PHASE1
• CIME - Combination of Immune checkpoint in locally advanced or metastatic MSI/dMMR Esogastric adenocarcinomas : A multicenter, randomised, comparative, open-label Phase III aiming to compare the survival of patients with locally advanced or metastatic MSI/dMMR Esogastric adenocarcinomas treated by a combination of Immune checkpoint inhibitors (botensilimab + balstilimab) versus the standard of care (FOLFOX/XELOX + nivolumab) — TERMINATED · PHASE3
• Effects of the ABCA1 inducer R3R01 on albuminuria levels in diabetic kidney disease — TERMINATED · PHASE2
• A randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and quality of life outcomes of Vi-Siblin in patients with low anterior resection syndrome following rectal cancer surgery. — NOT_YET_RECRUITING · PHASE2
• Whole body HER3 quantification with radiolabelled Patritumab deruxtecan (HER3-DXd) PET/CT — TERMINATED · PHASE2
• Accelerator-based BNCT for head and neck carcinoma — OTHER · PHASE1
• MetAddon: Methadone as co-analgesic for patients with metastatic bone pain: a double-blind randomized controlled trial — TERMINATED · PHASE4

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