High-risk Prostate Cancer Clinical Trials

32 clinical trials for High-risk Prostate Cancer across international registries, including 15 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Radiation Therapy Approaches for People With Prostate Cancer — RECRUITING · PHASE2
• Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer — RECRUITING · PHASE2
• Androgen-responsive POSLUMA-guided Intra-prostatic Boost — RECRUITING · PHASE2
• Phase III Adaptive Adaptive Stereostactic Body Radiotherapy (SBRT) With Dose Escalation for High-Risk Prostate Cancer — RECRUITING · NA
• Serial PSMA PET for Therapy Monitoring in Clinically Significant Prostate Cancer — RECRUITING
• Comparison of 177Lu-PSMA-617 and 225Ac-PSMA-617 — RECRUITING · PHASE1
• A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss — RECRUITING · PHASE2
• A Platform Study of Epigenetic Therapy Before Prostatectomy in Men With Prostate Cancer — RECRUITING · PHASE1
• Delayed Pelvic Imaging With [68]Ga-PSMA PET/CT in a Patient With High-risk Prostate Cancer. — RECRUITING · NA
• Tb-PSMA-I&T Radionuclide Before Radical Prostatectomy in Patients With Locally Advanced Prostate Cancer - TbeforePROST Trial. — RECRUITING · PHASE1
• PRospective Observational Study of STereotactic Body rAdiation Therapy With Androgen Deprivation Therapy for Organ-confined High-risk Prostate Cancer: the PROSTAR Trial — RECRUITING
• Surgical Treatment With or Without Apalutamide in Subjects With High Risk Prostate Cancer Who Are Candidates for Radical Prostatectomy and Staged as Oligometastatic With PSMA-PET — RECRUITING · PHASE2
• FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer — RECRUITING · PHASE2
• Neoadjuvant Intense Endocrine Therapy for High Risk and Locally Advanced Prostate Cancer — RECRUITING · PHASE2
• Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery — RECRUITING · PHASE2
• Contribution of Canine Detection in the Diagnostic Strategy of High-risk Prostate Cancer (Prostate-K9-Detect) — COMPLETED
• Predictors of Nodal and Distant Metastatic Disease Detected by PSMA PET in Treatment-Naïve High-Risk Prostate Cancer: A Czech Multicentre Cohort Study — ACTIVE_NOT_RECRUITING
• Immunotherapy With N 803, ETBX-071, and M-CENK in Combination With Radiation for Participants With High-Risk Prostate Cancer. — WITHDRAWN · PHASE2
• Immunotherapy Before and After Surgery — WITHDRAWN · PHASE2
• COMBINED PSMA-PET/CT AND MRI STAGING IN INTERMEDIATE AND HIGH-RISK PATIENTS PROSTATA-CANCER (COMBINE-P) — ACTIVE_NOT_RECRUITING
• Conventional Versus Hypofractionated Radiation in High Risk Prostate Patients — TERMINATED · NA
• A Confirmatory, Prospective, Open-label, Single-arm, Reader-blinded Multi-centre Phase 3 Study to Assess the Diagnostic Accuracy of Ferumoxtran-10-enhanced Magnetic Resonance Imaging (MRI) and Unenhanced MRI in Reference to Histopathology in Newly-diagnosed Prostate Cancer (PCA) Patients, Scheduled for Radical Prostatectomy (RP) With Extended Pelvic Lymph Node Dissection (ePLND). — OTHER
• An open label, single-arm, phase 2 study of neoadjuvant PEMbrolizumab before radical PROstatectomy (PEM-PRO) in high-risk prostate cancer patients — OTHER · PHASE2
• Fluzoparib and Abiraterone in the preSurgery Treatment of Prostate Cancer: FAST Trial — OTHER · PHASE2
• An Open-label, Single-arm, Rater-blinded, Multicenter Phase 1/2 Study to Assess Safety and Diagnostic Accuracy and Radiotherapeutic Implications of Pre-operative Ga-68-PSMA-11 PET/CT Imaging in Comparison to Histopathology, in Newly-diagnosed Prostate Cancer (PCA) Patients at High Risk for Metastasis, Scheduled for Radical Prostatectomy (RP) With Extended Pelvic Lymph Node Dissection (EPLND) — OTHER
• Novel Imaging in Staging of Primary Prostate Cancer — COMPLETED · NA
• Enzalutamide/Leuprolide +/- Abiraterone/Pred in Prostate — COMPLETED · PHASE2
• Neoadjuvant BKM120 in High-risk Prostate Cancer — TERMINATED · PHASE2
• Ga-68-PSMA-11 in High-risk Prostate Cancer — COMPLETED · PHASE1
• PROspective Multicenter Observational Study on Elective Pelvic Nodes Irradiation. — OTHER
• Stereotactic Pelvic Brachytherapy With HDR Boost for Dose Escalation in High Tier Intermediate and High Risk Prostate ca — OTHER · NA
• Hypofractionated Intensity Modulated Radiation Therapy Plus Hormonal Therapy in Patients With High Risk Prostate Cancer — COMPLETED · NA

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