HPV Positive Oropharyngeal Squamous Cell Carcinoma Clinical Trials

42 clinical trials for HPV Positive Oropharyngeal Squamous Cell Carcinoma across international registries, including 16 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study — RECRUITING · PHASE2
• CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs — RECRUITING · PHASE2
• The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial) — RECRUITING · PHASE2
• A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects With HPV Positive HNSCC. — RECRUITING · PHASE1
• E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers — RECRUITING · PHASE2
• E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers — RECRUITING · PHASE1
• Reduced Elective Nodal and CTV Dose for HPV+ Oropharyngeal Squamous Cell Carcinoma — RECRUITING · PHASE2
• Intranasal WSK-IM05 Vaccine Plus Tislelizumab as Neoadjuvant Therapy for HPV+ OPSCC — RECRUITING · PHASE1
• De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx — RECRUITING
• A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC) — RECRUITING · PHASE2
• A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC) — RECRUITING · PHASE2
• A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer — RECRUITING · PHASE1
• Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma — RECRUITING · PHASE2
• Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) — RECRUITING · PHASE2
• De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) — RECRUITING · NA
• Safety and Efficacy of VB10.16 and Pembrolizumab in Patients with Head-Neck Squamous Cell Carcinoma — RECRUITING · PHASE1
• A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED) — NOT_YET_RECRUITING · PHASE2
• Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma — COMPLETED · NA
• Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer — ACTIVE_NOT_RECRUITING · PHASE2
• Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCs — NOT_YET_RECRUITING · PHASE1
• Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living With HIV — ACTIVE_NOT_RECRUITING · PHASE3
• Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0) — NOT_YET_RECRUITING · PHASE2
• Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation — NOT_YET_RECRUITING · PHASE2
• TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers — ACTIVE_NOT_RECRUITING · PHASE1
• Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma — ACTIVE_NOT_RECRUITING · PHASE3
• A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma — COMPLETED · PHASE1
• The SPOT-HPV Study — COMPLETED
• ctDNA Liquid Biopsy for Early Assessment of Residual Disease in HPV-associated Head and Neck Cancer (Clear-HPVca) — COMPLETED
• A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors — ACTIVE_NOT_RECRUITING · PHASE1
• Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC — COMPLETED · PHASE2
• A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC) — ACTIVE_NOT_RECRUITING
• Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors — TERMINATED · PHASE1
• Improving Detection and Early Action for HPV-positive Oropharynx Cancer — COMPLETED · NA
• Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck — COMPLETED · PHASE1
• Surgery and Reducing Ionizing Radiation of the Unknown Primary — NOT_YET_RECRUITING · PHASE2
• Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer — OTHER · PHASE2
• Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer — TERMINATED · PHASE2
• This SCR-103 Protocol Will Permit Sites to Proactively Assess TAA, HLA and HPV-16 Status in Patients With Selected Solid Tumors to Determine Suitability for Repertoire Immune Medicines Treatment Protocols. — TERMINATED
• Weekly Cetuximab/RT Versus Weekly Cisplatin/RT in HPV-Associated Oropharyngeal Squamous Cell Carcinoma — OTHER · PHASE3
• ADXS 11-001 Vaccination Prior to Robotic Surgery, HPV-Positive Oropharyngeal Cancer — COMPLETED · PHASE2
• Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients — WITHDRAWN · PHASE2
• Interim Digital PET/CT in Predicting Outcomes for Participants With Locally Advanced Oropharyngeal Cancer Undergoing Chemoradiation Therapy — WITHDRAWN · NA

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