Huntington's Disease Clinical Trials

97 clinical trials for Huntington's Disease across international registries, including 7 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease — RECRUITING · PHASE1
• A randomized, placebo-controlled, double-blind Phase 3 study to evaluate the efficacy, safety and tolerability of votoplam in participants with Huntington’s Disease — RECRUITING · PHASE3
• An Extension of SKY-0515 in Participants With Huntington's Disease — RECRUITING · PHASE2
• A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease — RECRUITING · PHASE1
• HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease — RECRUITING
• iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009 — RECRUITING · PHASE1
• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort — RECRUITING
• AN OPEN LABEL EXTENSION STUDY TO INVESTIGATE THE LONG TERM SAFETY, TOLERABILITY AND EFFICACY OF PF-02545920 IN SUBJECTS WITH HUNTINGTON’S DISEASE WHO PREVIOUSLY COMPLETED STUDY A8241021 — TERMINATED · PHASE2
• Efficacy, Safety and Tolerability of AFQ056 in Patients with Huntington's Disease in Reducing Chorea — TERMINATED · PHASE2
• A study to determine how safe and tolerable the study drug is, when given to patients with Huntingtons Disease. — COMPLETED · PHASE2
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease — ACTIVE_NOT_RECRUITING · PHASE1
• A Phase 2/3 Randomized, Double Blind, Placebo-Controlled, Dose Ranging Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants with Huntington’s Disease — NOT_YET_RECRUITING · PHASE3
• Real World Effectiveness and Safety of Deutetrabenazine in Adult Chinese Patients With Huntington's Disease (HD) Chorea in China — COMPLETED · PHASE4
• (ASK-HD-01-CS-101) An Open-Label Phase I/II Dose Finding Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Striatal Administration of AB-1001 in Adult Subjects with Early Manifest Huntington’s Disease (HD) — TERMINATED · PHASE2
• Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease — COMPLETED
• A Positron Emission Tomography (PET) study to examine the properties of a novel radioligand's suitability for imaging mutant huntingtin — TERMINATED · PHASE1
• Biology-Driven Cognitive Profiling in Huntington's Disease — ACTIVE_NOT_RECRUITING
• A Study to Evaluate ALN-HTT02 in Adult Patients with Huntington’s Disease — TERMINATED · PHASE1
• A Phase Ib/II Randomized, Double-Blind Study to Explore Safety, Tolerability, and Efficacy Signals of Multiple Doses of Striatally-Administered rAAV5-miHTT Total Huntingtin Gene (HTT) Lowering Therapy (AMT‑130) in Early Manifest Huntington Disease — TERMINATED · PHASE2
• Multicentric trial on the use of combined therapy of Thiamine and biotine in patients with Huntington´s disease. — TERMINATED · PHASE2
• A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease — TERMINATED · PHASE3
• Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease — ACTIVE_NOT_RECRUITING · PHASE1
• A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD) — COMPLETED · PHASE2
• A Phase 2a, Randomized, Placebo-controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of PTC518 in Subjects with Huntington’s Disease — OTHER · PHASE2
• ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders — ACTIVE_NOT_RECRUITING · NA
• Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease — COMPLETED · PHASE1
• At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions — COMPLETED
• A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery — COMPLETED
• Examination of Quantitative Electroencephalographic (QEEG) Biomarkers in Huntington's Disease — COMPLETED
• Individuals Patterns of Disclosure About Huntington s Disease (HD) and the Association With Adaptation to HD — COMPLETED
• A Study of Treatment With Pridopidine (ACR16) in Participants With Huntington's Disease — COMPLETED · PHASE3
• Tolerability, Safety, and Activity of SRX246 in Irritable Subjects With Huntington's Disease — COMPLETED · PHASE2
• HD-Charge: Indirect and Out-of-Pocket Costs of Huntington's Disease in the United States — COMPLETED
• A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine) — OTHER · PHASE4
• A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi — COMPLETED · PHASE2
• Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease — TERMINATED · PHASE1
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139) — COMPLETED · PHASE2
• Safety and Tolerability of WVE-120101 in Patients With Huntington's Disease — TERMINATED · PHASE1
• A Study Evaluating if Pridopidine is Safe, Efficacious, and Tolerable in Patients With Huntington's Disease — TERMINATED · PHASE2
• The Effect of Video Game Exercise on Dynamic Balance and Gait in Individuals With Huntington's Disease — COMPLETED · NA
• A Phase 2, to Evaluating the Safety and Efficacy of Pridopidine Vs Placebo for Symptomatic Treatment in Patients With Huntington's Disease — COMPLETED · PHASE2
• Study of Memantine to Treat Huntington's Disease — COMPLETED · PHASE4
• Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging — COMPLETED · NA
• A Clinical Study in Participants With Huntington's Disease (HD) to Assess Efficacy and Safety of Three Oral Doses of Laquinimod — COMPLETED · PHASE2
• Electronic-health Application To Measure Outcomes REmotely Clinical Trial — COMPLETED · NA
• Brain Stimulation in Movement Disorders — COMPLETED · NA
• Follow-up Measurement of Brain PDE10A Enzyme Levels in Huntington´s Disease Gene Expansion Carriers — COMPLETED · PHASE1
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 443139 in Participants With Early Manifest Huntington's Disease — COMPLETED · PHASE1
• Feasibility and Acceptability of Implementing a Clinic-based Physical Activity Coaching Intervention in People With Premanifest and Early Stage HD — COMPLETED · PHASE1
• Exploring Computerised Cognitive Training for People With Huntington's Disease — COMPLETED · NA

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