Hypoplastic Left Heart Syndrome Clinical Trials

61 clinical trials for Hypoplastic Left Heart Syndrome across international registries, including 10 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease — RECRUITING
• Differences in ultrasound-measured liver and spleen stiffness between two established methods – ELastography of VISceral organs (Liver & Spleen) — RECRUITING
• Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome — RECRUITING · NA
• Functional and structural analysis of the microcirculation and endothelial glycocalyx, as well as Proteomicsanalysis on patients with congenital heart defects especially with univentricular heart and Fontan-palliation — RECRUITING
• Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) — RECRUITING · PHASE3
• National Collaborative to Improve Care of Children With Complex Congenital Heart Disease — RECRUITING
• Effect of Fetal Aortic Valvuloplasty on Outcomes — RECRUITING
• An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease — RECRUITING
• App-based interstage monitoring in children with congenital heart defects — RECRUITING
• Long-term Early Development Research in Children with Hypoplastic Left Heart Syndrome — RECRUITING
• Investigation of the physical capacity of patients aged 10–40 years with Fontan circulation, as a function of the system ventricle, based on spiroergometric data collected from the patient cohort at the Department of Pediatric Cardiology at the University Hospital of Bonn — OTHER
• The CHILD Trial: Hypoplastic Left Heart Syndrome Study. — COMPLETED · PHASE1
• Cross-sectional study to assess the health-related quality of life in patients with complex univentricular heart defects after Fontan surgery — OTHER
• 3D Modalities for Medical Student Education of Congenital Heart Disease — COMPLETED · NA
• Liver fibrosis associated with Fontan circulation - evaluation of diagnostic methods and potential risk factors — OTHER
• Seeking for Perfected Aortic Arch Reconstruction Using a Graphically Designed Patient-specific Surgical Patch — NOT_YET_RECRUITING · NA
• Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome — ACTIVE_NOT_RECRUITING · PHASE2
• Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. — ACTIVE_NOT_RECRUITING · PHASE2
• Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients with Hypoplastic Left Heart Syndrome (HLHS) — NOT_YET_RECRUITING · PHASE1
• Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients — COMPLETED · NA
• Cerebral Anatomy, Hemodynamics and Metabolism — COMPLETED
• Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation — TERMINATED
• Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period — COMPLETED · NA
• Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome — TERMINATED · PHASE1
• Maternal Hyperoxygenation in Congenital Heart Disease — COMPLETED · PHASE1
• Retrospective, Single-Centre Data Collection Study of the Effectiveness and Safety of a Specially Designed Ductus Arteriosus Self-Expanding Stent (Sinus-SuperFlex-DS, SSF) in the “Giessen Hybrid” Approach — OTHER
• Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy — TERMINATED · PHASE1
• Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle — OTHER · PHASE1
• Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome — COMPLETED · NA
• Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease — OTHER · NA
• Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike) — COMPLETED · NA
• Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery — COMPLETED · PHASE1
• Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome — COMPLETED · PHASE1
• Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS) — COMPLETED · PHASE2
• Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology — COMPLETED · PHASE1
• Genetic Determinants of Congenital Heart Disease Outcomes — COMPLETED
• Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome — TERMINATED · PHASE1
• A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation — COMPLETED
• Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) — COMPLETED · NA
• PHASE IIB STUDY OF INTRAMYOCARDIAL INJECTION OF AUTOLOGOUS UMBILICAL CORD BLOOD DERIVED MONONUCLEAR CELLS DURING STAGE II SURGICAL REPAIR OF HYPOPLASTIC LEFT HEART SYNDROME (AUTO CELL-II) — NOT_YET_RECRUITING · PHASE2
• Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease — WITHDRAWN · NA
• Erythropoetin Neuroprotection for Neonatal Cardiac Surgery — COMPLETED · PHASE1
• Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a Newborn — COMPLETED
• SVRII Family Factors Study — COMPLETED
• Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques — TERMINATED
• Ambrisentan in Single Ventricle — COMPLETED · PHASE2
• Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes — COMPLETED
• Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood Procedure — COMPLETED · NA
• Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease — OTHER · NA
• Positive Pressure Ventilation and Sternal Closure in HLHS — WITHDRAWN

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