Leptomeningeal Disease Clinical Trials

20 clinical trials for Leptomeningeal Disease across international registries, including 8 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study — RECRUITING · NA
• Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMD — RECRUITING · PHASE2
• Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis — RECRUITING · PHASE2
• Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease — RECRUITING · NA
• Non Interventional German Leptomeningeal Disease Register — RECRUITING
• Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease — RECRUITING · PHASE2
• Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) — RECRUITING · PHASE1
• Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis — RECRUITING
• Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma — NOT_YET_RECRUITING · PHASE1
• A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer — ACTIVE_NOT_RECRUITING · PHASE1
• ctDNA-Guided Intraventricular Therapy for CNS Malignancies — NOT_YET_RECRUITING · NA
• Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease — ACTIVE_NOT_RECRUITING · PHASE1
• A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) — ACTIVE_NOT_RECRUITING · PHASE1
• Intrathecal application of PD-1 antibody in metastatic solid tumors with leptomeningeal disease — TERMINATED · PHASE2
• Avelumab With Radiotherapy in Patients With Leptomeningeal Disease — COMPLETED · PHASE1
• B7-H3.CD28Z.CART in CNS Neoplasms — NOT_YET_RECRUITING · PHASE1
• Study Assessing QBS72S For Treating Brain Metastases — ACTIVE_NOT_RECRUITING · PHASE2
• Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD — TERMINATED · PHASE2
• A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide — TERMINATED
• Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC — TERMINATED · PHASE1

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