Locally Advanced Breast Cancer Clinical Trials

74 clinical trials for Locally Advanced Breast Cancer across international registries, including 16 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• A Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3CA-mutated, Hormone Receptor-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer — RECRUITING
• A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer — RECRUITING · PHASE1
• PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer — RECRUITING · PHASE1
• Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer — RECRUITING · PHASE3
• Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy — RECRUITING · PHASE2
• A Study of Pembrolizumab and Cryoablation in People With Breast Cancer — RECRUITING · PHASE1
• Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer — RECRUITING · PHASE2
• I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer — RECRUITING · PHASE2
• A Phase I/II Study of FWD1802 in Patients With ER+/HER2- Advanced BC. — RECRUITING · PHASE1
• A Phase 3 Study of HRS-8080 Versus Treatment Chosen by Physicians in Locally Advanced and Metastatic Breast Cancer — RECRUITING · PHASE3
• Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer — RECRUITING · PHASE1
• A Phase Ib/II Study to Evaluate Multiple Combination Therapies of FWD1802 in Patients With ER+/HER2- BC — RECRUITING · PHASE1
• Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer — RECRUITING · PHASE1
• Adjuvant Study of Pyrotinib in HER-2 Positive Breast Cancer — RECRUITING · PHASE3
• Breast Cancer Exercise Intervention Study — RECRUITING · NA
• To Evaluate the Efficacy and Safety of Ipsilateral Supraclavicular Lymph Node Dissection for Breast Cancer Patients — RECRUITING
• SMP-656 for HER2-Positive Advanced Breast Cancer — NOT_YET_RECRUITING · PHASE2
• Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer — ACTIVE_NOT_RECRUITING · NA
• A Study of the Efficacy, Safety and Pharmacokinetics of RPH-051 and Perjeta® in Combination With Trastuzumab and Docetaxel as the 1st Line Therapy in Patients With HER2-positive Breast Cancer — ACTIVE_NOT_RECRUITING · PHASE3
• Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy — ACTIVE_NOT_RECRUITING · PHASE2
• A Study to Assess CLBR001+ABBV-461 in Subjects With Locally Advanced or Metastatic Breast Cancer — TERMINATED · PHASE1
• A Study of U3-1402 (Patritumab Deruxtecan) in Subjects With Metastatic Breast Cancer — COMPLETED · PHASE2
• Trastuzumab Rezetecan (T-DXh) in HER2+ Breast Cancer With Non-pCR After TCbHP — NOT_YET_RECRUITING · PHASE4
• Targeting Stress-Driven Inflammatory and Angiogenic Pathways With Brief ACT to Enhance Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer — NOT_YET_RECRUITING · NA
• Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer — NOT_YET_RECRUITING
• Trastuzumab Deruxtecan in First-line HER2-positive Locally Advanced/MBC Patients Resistant to Trastuzumab+Pertuzumab — TERMINATED · PHASE2
• A Study of Samuraciclib and Elacestrant in Participants With Metastatic or Locally Advanced HR+/HER2-negative Breast Cancer — COMPLETED · PHASE1
• Three Fraction Radiation to Induce Immuno-Oncologic Response — ACTIVE_NOT_RECRUITING · NA
• Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy — NOT_YET_RECRUITING · NA
• Onvansertib + Paclitaxel In TNBC — ACTIVE_NOT_RECRUITING · PHASE1
• A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer — COMPLETED · PHASE3
• JSKN016 in Combination With D-0502 for Locally Advanced or Metastatic HR-Positive, HER2-Negative Breast Cancer — NOT_YET_RECRUITING · PHASE1
• HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer — COMPLETED · PHASE1
• SHR-A1811 Plus Pertuzumab as Neoadjuvant Therapy for Early or Locally Advanced HR-Positive HER2-Positive Breast Cancer: A Prospective, Open-Label, Phase II Study — NOT_YET_RECRUITING · PHASE2
• A Study of Samuraciclib in Combination With Fulvestrant in Metastatic or Locally Advanced Breast Cancer in Adult Participants — COMPLETED · PHASE2
• A Clinical Study to Explore the Safety, Tolerability, and Efficacy of Recombinant Human nsIL12 Oncolytic Adenovirus Injection (BioTTT001) Combined With Neoadjuvant Treatment for Locally Advanced Breast Cancer — WITHDRAWN · PHASE1
• Pyrotinib Maleate Tablets in Combination With Dalpiciclib Isethionate Tablets and Standard Endocrine Therapy — NOT_YET_RECRUITING · PHASE1
• Copanlisib in Combination With T-DM1 in Pretreated Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer — TERMINATED · PHASE1
• Impact of Endocrine Therapy and Abemaciclib on Host and Tumor Immune Cell Repertoire/Function in Advanced ER+/HER2- Breast Cancer — COMPLETED · PHASE2
• Safety, Pharmacokinetics and Anti-tumor Activity of RP12146, in Patients With Solid Tumors — COMPLETED · PHASE1
• A Study of Treatment Patterns and Outcomes in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced or Metastatic Breast Cancer — COMPLETED
• Efficacy and Safety of Tenalisib (RP6530), in Patients With Locally Advanced or Metastatic Breast Cancer — COMPLETED · PHASE2
• Neoadjuvant Treatment of Locally-advanced Breast Cancer Patients With Ribociclib and Letrozole — COMPLETED · PHASE2
• Predicting Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer — NOT_YET_RECRUITING
• Repeatability of 68-GaNOTA-Anti-HER2 VHH1 PET/CT in Breast Carcinoma Patients — OTHER · PHASE2
• Influence of Intermittent Fasting on Locally Advanced Breast Cancer Patients — OTHER · NA
• The p53 Breast Cancer Trial — ACTIVE_NOT_RECRUITING · PHASE2
• The Choice of Treatment Methods and Efficacy of LABC — OTHER · NA
• Real-World Data of Clinicopathological Characteristics and Management of Breast Cancer Patients According to HER2 Status — COMPLETED
• Neoadjuvant Dose-Dense For Early Her2Neu Positive Breast Cancer — TERMINATED · PHASE2

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