Locally Advanced Head and Neck Squamous Cell Carcinoma Clinical Trials

39 clinical trials for Locally Advanced Head and Neck Squamous Cell Carcinoma across international registries, including 14 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

CLEAR (Cervical Lymphatic Exclusion in Adjuvant Radiation) — RECRUITING · PHASE2
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy — RECRUITING · PHASE3
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer — RECRUITING · PHASE1
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors — RECRUITING · PHASE1
Becotatug Vedotin (MRG003) in Combination With PD-1 Inhibitor Versus PD-1 Inhibitor for the Treatment of EGFR-positive, CPS≥1 Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma — RECRUITING · PHASE3
Clinical Trial Comparing Induction Treatment With EGFR-ADC MRG003 Alone or in Combination With the Anti PD1 Pucotenlimab, Followed by Radiochemotherapy in Locally Advanced Squamous Cell Cancers of the Head and Neck — RECRUITING · PHASE2
Low-Dose Radiotherapy and Anti-PD-1 Immunotherapy as Neoadjuvant Treatment for Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma — RECRUITING · PHASE2
Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma — RECRUITING · NA
Low-Dose Weekly vs High-Dose Cisplatin — RECRUITING · NA
Tirilizumab with Albumin-bound Paclitaxel and Cisplatin for Locally Advanced Resectable Oral Squamous Cell Carcinoma — RECRUITING · PHASE2
Study of Cemiplimab - TP Induction Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck — RECRUITING · PHASE1
De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCC — RECRUITING · PHASE1
A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood — RECRUITING · PHASE2
TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. — RECRUITING
A Study of JNJ-90301900 in Combination with Concurrent Chemoradiation Therapy in LA HNSCC — TERMINATED · PHASE1
[18F]-AraG PET Imaging in LA HNSCC — NOT_YET_RECRUITING · PHASE1
Group-Mediated Cognitive Behavioral Resistance Exercise Intervention in Head and Neck Cancer Patients Undergoing Chemoradiation Treatment — COMPLETED · NA
Neoadjuvant Radio-immunotherapy Versus Immunotherapy Alone for Locally Advanced HNSCC — NOT_YET_RECRUITING · PHASE2
A phase II trial evaluating treatment intensification with Ezabenlimab in patients with PD-L1–expressing, locally advanced head and neck squamous cell carcinoma (LA-HNSCC) with minimal residual disease (MRD) as detected by circulating tumor DNA (ctDNA) after curative-intent chemoradiation — NOT_YET_RECRUITING · PHASE2
Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer — ACTIVE_NOT_RECRUITING · PHASE1
Sintilimab-Nimotuzumab Induction Followed by Chemoradiation-Nimotuzumab in LA-HNSCC: Single-Arm Phase II — NOT_YET_RECRUITING · PHASE2
Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition — COMPLETED · PHASE2
Combined Pembrolizumab and Lenvatinib after definitive Chemoradiation of locally advanced HNSCC in PD-L1 positive patients (CPS≥1) — TERMINATED · PHASE2
Randomized Phase 2 trial of induction treatment of anti-PD-1 pucotenlimab and EGFR-ADC MRG003 or EGFR-ADC alone followed by chemoradiotherapy in locally advanced head and neck squamous cell carcinoma (LA-SCCHN). — TERMINATED · PHASE2
Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck — ACTIVE_NOT_RECRUITING · PHASE2
Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN — WITHDRAWN · PHASE2
Low dose cisplatin weekly versus high dose cisplatin every three weeks in primary chemoradiation in sarcopenic patients with head and neck squamous cell carcinoma — TERMINATED · PHASE4
Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer — COMPLETED · PHASE1
Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma — SUSPENDED · PHASE2
Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin — COMPLETED · PHASE2
Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC — COMPLETED · PHASE2
Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma — NOT_YET_RECRUITING · PHASE2
Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck Cancer — WITHDRAWN · NA
A Real-world Study of the Efficacy and Safety of Nimotuzumab in Combination With Chemoradiotherapy for LASCCHN — COMPLETED
Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma — OTHER · PHASE2
Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC — OTHER · PHASE1
Efficacy Study of Genexol-PM and Cisplatin in Locally Advanced Head and Neck Cancer — COMPLETED · PHASE2
the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer — OTHER · PHASE2
Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SCCHN — OTHER · PHASE2

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