Locally Advanced Rectal Cancer Clinical Trials

116 clinical trials for Locally Advanced Rectal Cancer across international registries, including 28 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer — RECRUITING · NA
• THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy — RECRUITING · NA
• NG-350A Plus Chemoradiotherapy for Locally Advanced Rectal Cancer — RECRUITING · PHASE1
• Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer — RECRUITING · PHASE2
• Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal Cancer — RECRUITING
• A Single-arm Phase II Clinical Study of Camrelizumab Combined With Long-course Chemoradiotherapy for Total Neoadjuvant Therapy in Locally Advanced Low pMMR/MSS Rectal Cancer — RECRUITING · PHASE2
• Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients — RECRUITING · NA
• GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients — RECRUITING
• CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer — RECRUITING · PHASE1
• A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer — RECRUITING · PHASE2
• SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer — RECRUITING
• Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC) — RECRUITING · PHASE2
• Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer. — RECRUITING · PHASE2
• Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study — RECRUITING · PHASE3
• Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer — RECRUITING · NA
• TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer — RECRUITING · PHASE3
• Preoperative Chemoradiotherapy Combined With Consolidation or Induction NALIRIFOX in Rectal Cancer. — RECRUITING · NA
• MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal Cancer — RECRUITING · NA
• Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study — RECRUITING · PHASE2
• Preoperative Radiotherapy And ASTX660 in Rectum Cancer — RECRUITING · PHASE1
• Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer — RECRUITING · PHASE2
• Organ Preservation in Locally Advanced Rectal Cancer — RECRUITING · NA
• A trial comparing standard treatment versus a new combination of treatments for locally advanced rectal cancer. — OTHER · PHASE3
• EXCITE: Erbitux, Xeloda, Campto, Irradiation Then Excision for locally advanced rectal cancer. (North West Clinical Oncology Group-04 on behalf of the NCRI rectal cancer subgroup) — COMPLETED · PHASE2
• Phase II study of Durvalumab (MEDI4736) plus Total Neoadjuvant Therapy (TNT) in locally advanced rectal cancer — ACTIVE_NOT_RECRUITING · PHASE2
• An open label study of the effect of Xeloda and radiotherapy on pathological response rate in patients with locally advanced rectal cancer. — COMPLETED · PHASE2
• ACO/ARO/AIO-18.2 Preoperative FOLFOX versus postoperative risk-adapted chemotherapy in patients with locally advanced rectal cancer and low risk for local failure: A randomized phase III trial of the German Rectal Cancer Study Group — TERMINATED · PHASE3
• Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Field I) — SUSPENDED · PHASE2
• To Explore a Single-arm Phase II Study on Intestinal Microbiota Transplantation Combined With Neoadjuvant Immunotherapy and Chemoradiotherapy for Locally Advanced Rectal Cancer Under MSS/pMMR — NOT_YET_RECRUITING · NA
• Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29 — ACTIVE_NOT_RECRUITING · PHASE2
• Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence — ACTIVE_NOT_RECRUITING · PHASE2
• PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer — ACTIVE_NOT_RECRUITING · PHASE2
• TIME in Immunotherapy Combined With nCRT for Rectal Cancer — ACTIVE_NOT_RECRUITING · PHASE2
• Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer — NOT_YET_RECRUITING · PHASE2
• Multicentre, open-label, randomised, controlled, parallel-arms, phase III, clinical trial of Neoadjuvant FOLFOXIRI and Chemoradiotherapy versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy, followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer: MEND-IT II — TERMINATED · PHASE3
• Phase II study of Short-course radiotherapy followed by consolidation chemotherapy with the Triplet FOLFOXIRI as total neoadjuvant therapy for locally advanced rectal cancer: the ShorTrip trial — TERMINATED · PHASE2
• Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer — NOT_YET_RECRUITING · PHASE2
• Intraoperative Electron Radiotherapy in Rectal Cancer - A Feasibility Trial — ACTIVE_NOT_RECRUITING · NA
• SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal Cancer — NOT_YET_RECRUITING · PHASE3
• Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer — TERMINATED · PHASE1
• Short-Course RT Plus CAPOX and Tislelizumab vs Long-Course CRT Plus Tislelizumab for Locally Advanced Rectal Cancer — NOT_YET_RECRUITING · PHASE2
• ONCO-RET: Supervised Resistance Training During Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer — NOT_YET_RECRUITING · NA
• XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients — NOT_YET_RECRUITING · PHASE2
• A Pospective, Single-arm, Multicenter Clinical Trial Evaluating Preoperative Neoadjuvant mFOLFOX6 Chemotherapy in Combination With PD1 Monoclonal Antibody in MSS/pMMR Locally Advanced Rectal Cancer — ACTIVE_NOT_RECRUITING · NA

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