Major Depressive Disorder Clinical Trials

2046 clinical trials for Major Depressive Disorder across international registries, including 284 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Natural History of Depression, Bipolar Disorder and Suicide Risk — RECRUITING
• Home-Based tDCS Treatment Of Major Depressive Disorder — RECRUITING · NA
• Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial — RECRUITING · NA
• A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder — RECRUITING · PHASE3
• Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder — RECRUITING · PHASE1
• The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder — RECRUITING · PHASE3
• A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression — RECRUITING · PHASE2
• Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy — RECRUITING · PHASE2
• Positioning of Esketamine Treatment in the Real-world Management of Depression — RECRUITING · PHASE4
• Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression — RECRUITING · NA
• Pain and Major Depressive Disorder — RECRUITING · NA
• NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) — RECRUITING · PHASE3
• NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) — RECRUITING · PHASE3
• Defining Neurobiological Links Between Substance Use and Mental Illness — RECRUITING · NA
• A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend) — RECRUITING · PHASE3
• Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders — RECRUITING · PHASE2
• ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response — RECRUITING · PHASE2
• A Study of Vortioxetine in Japanese Pediatric Patients With Major Depressive Disorder — RECRUITING · PHASE3
• Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements — RECRUITING
• Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine — RECRUITING · PHASE1
• A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder — RECRUITING · PHASE3
• Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder — RECRUITING · PHASE2
• An Open-Label Study of Azetukalner in Major Depressive Disorder — RECRUITING · PHASE3
• A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3) — RECRUITING · PHASE3
• Closed-Loop Deep Brain Stimulation for Major Depression — RECRUITING · NA
• Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder — RECRUITING · PHASE3
• DBS for Depression — RECRUITING · NA
• Mindful Self-Compassion for Anxiety Disorders and Depression — RECRUITING · NA
• Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) — RECRUITING · PHASE2
• Evaluating Conversational Artificial Intelligence for Depression Management — RECRUITING · NA
• A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder — RECRUITING · PHASE2
• Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT — RECRUITING · NA
• A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) — RECRUITING · PHASE3
• Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) — RECRUITING · PHASE3
• A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety — RECRUITING · PHASE2
• RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS — RECRUITING · NA
• Early intervention with repetitive theta burst stimulation in adolescents and young adults with depressive disorders: a sequential Bayesian, randomized controlled pilot trial — RECRUITING
• Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy — RECRUITING · NA
• Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS) — RECRUITING · NA
• Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness — RECRUITING · PHASE2
• Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder — RECRUITING · PHASE3
• Pattern Separation in Major Depressive Disorder — RECRUITING · PHASE1
• Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) — RECRUITING · PHASE3
• An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study) — RECRUITING · PHASE2
• Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents — RECRUITING · NA
• Inhaled DMT for Major Depressive Disorder — RECRUITING · PHASE2
• A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study) — RECRUITING · PHASE2
• A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate Azetukalner in Moderate-to-Severe Major Depressive Disorder — RECRUITING · PHASE3
• Cannabidiol Oil for Treatment-Resistant Major Depression — RECRUITING · PHASE1
• Predictors of Relapse in Major Depressive Disorder (PERFORM-D) — RECRUITING

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