Opioid-induced Constipation Clinical Trials

61 clinical trials for Opioid-induced Constipation across international registries, including 6 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Safety and Pharmacokinetics Study of Naldemedine in Paediatric Participants Receiving Opioids — RECRUITING · PHASE1
• Naldemedine in Clinical Practice in Cancer Patients With Opioid Induced CONstipation: Clinical Outcomes and Patient Experience — RECRUITING
• Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation — RECRUITING
• A MULTICENTER, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED, PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CB-5945 FOR THE TREATMENT OF OPIOID-INDUCED CONSTIPATION IN ADULTS TAKING OPIOID THERAPY FOR CHRONIC NON-CANCER PAIN — RECRUITING · PHASE3
• A MULTICENTER, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED, PHASE 3 STUDY TO EVALUATE THE LONG TERM SAFETY AND TOLERABILITY OF CB5945 FOR THE TREATMENT OF OPIOIDINDUCED CONSTIPATION IN ADULTS TAKING OPIOID THERAPY FOR CHRONIC NON-CANCER PAIN — RECRUITING · PHASE3
• A MULTICENTER, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED, PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CB-5945 FOR THE TREATMENT OF OPIOID-INDUCED CONSTIPATION IN ADULTS TAKING OPIOID THERAPY FOR CHRONIC NON-CANCER PAIN — RECRUITING · PHASE3
• An exploratory, randomised, active-controlled, double-blind, double-dummy, parallel group pilot study to determine the ability of oxycodone/naloxone prolonged release tablets (OXN) to reduce the number of subjects developing symptoms of opioid induced constipation compared to morphine prolonged release tablets (MOR PR) in opioid naïve, non-constipated subjects with non malignant pain that require opioid treatment. — COMPLETED · PHASE2
• A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Efficacy of TD-1211 in Subjects With Opioid-Induced Constipation — COMPLETED · PHASE2
• A Study of TD-1211 in Subjects With Opioid-Induced Constipation (OIC) — COMPLETED · PHASE2
• A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced Constipation — COMPLETED · PHASE1
• A Study to Assess the Safety, Tolerability and Clinical Activity of TD-1211 in Patients With Opioid-Induced Constipation — COMPLETED · PHASE2
• Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications — COMPLETED · PHASE2
• European Study of Opioid Induced Constipation — COMPLETED
• Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain — NOT_YET_RECRUITING · PHASE4
• Double-blind placebo-controlled cross-over MRI study to evaluate the effect of naloxegol and codeine on gastrointestinal motility and volumes — OTHER · PHASE4
• Naloxegol Drug Utilization Post Authorisation Safety Study — COMPLETED
• Naloxegol Health Outcome Post Authorisation Safety Study — TERMINATED
• Real World Observational Study of Naloxegol for Patients With Cancer Pain Diagnosed With OIC. — COMPLETED
• Naloxegol US PMR CV Safety. — OTHER
• Colonic Motor Patterns in Healthy Volunteers — COMPLETED · PHASE4
• Prucalopride Effects on Subjects With Chronic Non-cancer Pain Suffering From Opioid Induced Constipation — TERMINATED · PHASE3
• Study of Opioid-Induced Constipation 2 Project — COMPLETED
• Study of Opioid-Induced Constipation 1 Project — COMPLETED
• Study Evaluating Safety & Efficacy of Subcutaneous Methylnaltrexone on Opioid-Induced Constipation in Cancer Subjects — WITHDRAWN · PHASE4
• Evaluation of the Quality of Life of Patients With Opioid-induced Constipation Under Treatment With Naloxegol — COMPLETED
• A Study of Oral Methylnaltrexone (MNTX) for the Treatment of Opioid-Induced Constipation (OIC) in Participants With Chronic, Non-Malignant Pain — COMPLETED · PHASE3
• Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic Procedures — COMPLETED · PHASE2
• Compassionate Use Study of Methylnaltrexone — COMPLETED · NA
• Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain — COMPLETED · PHASE2
• Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation — TERMINATED · PHASE3
• Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation — TERMINATED · PHASE3
• Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation — TERMINATED · PHASE3
• The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation — TERMINATED · PHASE3
• A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy — COMPLETED · PHASE4
• Naloxone HCl PR Tablets in Patients With Opioid Induced Constipation — OTHER · PHASE3
• Evaluation of the Efficacy and Safety of ADL5945 for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain — COMPLETED · PHASE2
• To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation — COMPLETED · PHASE4
• Long Term Safety of Naldemedine — COMPLETED · PHASE3
• Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness — COMPLETED · PHASE4
• Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness — COMPLETED · PHASE4
• A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy — COMPLETED · PHASE2
• Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced Constipation — COMPLETED · PHASE3
• Efficacy and Safety of Naldemedine in Treating Opioid-induced Constipation — COMPLETED · PHASE3
• A 12-week Extension of the Phase III Study (D3820C00004) to Assess the Effect and Safety of NKTR-118 in Patients With Non-cancer-related Pain and Opioid-induced Constipation — COMPLETED · PHASE3
• A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC). — COMPLETED · PHASE4
• Study of Methylnaltrexone in Opioid-Induced Constipation Patients — OTHER · PHASE2
• Non-interventional Study Comparing Targiniq and Oxycodone/Laxatives — COMPLETED
• A Phase 2, Double-Blind, Multiple-Dose Escalation Study to Evaluate NKTR-118 (Oral PEG-Naloxol) in Patients With Opioid-Induced Constipation (OIC) — COMPLETED · PHASE2
• Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation — COMPLETED · PHASE3
• Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related Pain — TERMINATED · PHASE3

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