Primary Progressive Multiple Sclerosis Clinical Trials

52 clinical trials for Primary Progressive Multiple Sclerosis across international registries, including 5 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• A Phase 3, Randomized, Double-blind, Efficacy and Safety Study Comparing Orelabrutinib to Placebo in Patients With Primary Progressive Multiple Sclerosis — RECRUITING · PHASE3
• Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis — RECRUITING · PHASE1
• Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis — RECRUITING
• SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis — RECRUITING · PHASE1
• Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis — RECRUITING
• A study to evaluate how safe and effective 0.5 mg FTY720 is in delaying disability progression if taken once daily, in patients with PPMS — TERMINATED · PHASE3
• A pilot single-centre randomised controlled trial of recombinant human erythropoietin versus placebo in primary progressive multiple sclerosis. — TERMINATED · PHASE2
• A study to evaluate how safe and effective 0.5 mg fingolimod is in delaying disability progression if taken once daily, in patients with PPMS — COMPLETED · PHASE3
• A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis — COMPLETED · PHASE3
• A Phase III Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared with Ocrelizumab in Adult Patients with Primary Progressive Multiple Sclerosis — TERMINATED · PHASE3
• A Phase IIIb Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis — TERMINATED · PHASE3
• A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Ocrelizumab in Participants With Relapsing Multiple Sclerosis and Primary Progressive Multiple Sclerosis — ACTIVE_NOT_RECRUITING · PHASE4
• MAESTRO-4MS : "Allogenic Adipose tissue-derived Mesenchymal Stromal Cells for the treatment of Primary Progressive Multiple Sclerosis: an open-label phase I clinical trial." — TERMINATED · PHASE1
• Tear Analysis in the Diagnosis of Multiple Sclerosis — TERMINATED · NA
• Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis — ACTIVE_NOT_RECRUITING · PHASE3
• A Phase IIIB Multicenter, Randomized, Double-Blind, Controlled Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults with Primary Progressive Multiple Sclerosis — TERMINATED · PHASE3
• Safety and Efficacy of Monthly Long-acting IM Injection of 25mg or 40 mg GA Depot in Subjects With PPMS — TERMINATED · PHASE2
• Effect of Ocrelizumab on Choroid Plexus Changes in Patients With PPMS — COMPLETED
• Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis — COMPLETED · PHASE1
• Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS) — COMPLETED · PHASE3
• Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care — NOT_YET_RECRUITING
• A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS) — OTHER · PHASE3
• Metformin Treatment in Progressive Multiple Sclerosis — COMPLETED · PHASE1
• Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration — ACTIVE_NOT_RECRUITING · PHASE2
• IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple Sclerosis — SUSPENDED · PHASE1
• A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis — NOT_YET_RECRUITING · PHASE1
• Monitoring procedures in primary progressive multiple sclerosis (PPMS): Cognitive parameters in routine clinical practice — OTHER
• ACTH in Progressive Forms of MS — TERMINATED · PHASE2
• Transcutaneous Spinal Cord Stimulation (tSCS) in Therapy to Analyze Long-Term Effects on Spasticity and Gait Impairment in Multiple Sclerosis — OTHER
• Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With Ocrevus — COMPLETED
• Randomized, Single-blind, Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of Melatonin Administration in Patients With Multiple Progressive Primary Sclerosis (MELATOMS) — OTHER · PHASE2
• Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With PPMS (ORATORIO-Cortical) — COMPLETED
• Serial Collection of Primary Progressive Multiple Sclerosis Participants in the MURDOCK Study — COMPLETED
• Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis — TERMINATED · PHASE1
• Gray Matter Demyelination in Primary Progressive MS at 7T — OTHER
• Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714 — OTHER · PHASE3
• The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS — OTHER · NA
• A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo — COMPLETED · PHASE2
• Phase 1b Multiple Ascending Dose Study of Foralumab in Primary and Secondary Progressive MS — WITHDRAWN · PHASE1
• A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS — COMPLETED · PHASE4
• Idebenone for Primary Progressive Multiple Sclerosis — COMPLETED · PHASE1
• Dimethyl Fumarate Treatment of Primary Progressive Multiple Sclerosis — COMPLETED · PHASE2
• Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition — OTHER · PHASE2
• Video Game-based Therapy for Arm Weakness In Progressive Multiple Sclerosis — COMPLETED · NA
• Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis — COMPLETED · PHASE1
• Clinical Trial of Idebenone in Primary Progressive Multiple Sclerosis (IPPoMS) — COMPLETED · PHASE1
• Mitochondrial Dysfunction and Disease Progression — COMPLETED
• A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients — COMPLETED · PHASE1
• This Was an Open-label, Single-arm Extension Study (CFTY720D2306E1) to a Double-blind, Randomized Multicenter, Placebo-controlled, Parallel-group Core Study (CFTY720D2306) in PPMS. — TERMINATED · PHASE3
• Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS — OTHER · PHASE1

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