Rectal Adenocarcinoma Clinical Trials

90 clinical trials for Rectal Adenocarcinoma across international registries, including 26 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) — RECRUITING · PHASE3
• Family Communications After Genetic Testing — RECRUITING · NA
• SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC — RECRUITING · PHASE3
• FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery — RECRUITING · PHASE2
• A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial) — RECRUITING · PHASE2
• Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer — RECRUITING · PHASE1
• Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors — RECRUITING · PHASE2
• A Study of Tucatinib and Trastuzumab in People With Rectal Cancer — RECRUITING · PHASE2
• Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy — RECRUITING · PHASE2
• Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer — RECRUITING
• Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates — RECRUITING · PHASE2
• Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer — RECRUITING · PHASE1
• MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer — RECRUITING · PHASE1
• A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity — RECRUITING · NA
• Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer. — RECRUITING · PHASE2
• ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens — RECRUITING · NA
• SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC — RECRUITING · PHASE2
• Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer — RECRUITING
• Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer — RECRUITING · NA
• ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation — RECRUITING
• Evaluating Novel Therapies in ctDNA Positive GI Cancers — RECRUITING · PHASE3
• Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy — RECRUITING · NA
• Asian Watch-and-Wait Database (AWWD) — RECRUITING
• The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy for Organ-retention in Patients With MSS/pMMR Ultra Low Rectal Adenocarcinoma — RECRUITING · PHASE2
• Factors Affecting the Results of Treatment of Patients With Colorectal Cancer — RECRUITING
• Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems — RECRUITING
• The role of 3D laparoscopic rectal surgery: a randomised controlled trial — ACTIVE_NOT_RECRUITING
• Chemotherapy then Radiation then Immediate Curative Surgery for operable rectal cancer — TERMINATED · PHASE2
• NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC — NOT_YET_RECRUITING · PHASE2
• TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer — COMPLETED · PHASE1
• ctDNA-Informed Management of Early-Stage Rectal Cancer — NOT_YET_RECRUITING · PHASE2
• SCRT+mFOLFOX6+PD-1 Antibody and Targeted Therapy for High-Risk pMMR/MSS Rectal Cancer — COMPLETED · PHASE2
• SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer — NOT_YET_RECRUITING
• Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal — NOT_YET_RECRUITING
• A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer — NOT_YET_RECRUITING · PHASE2
• Young-Onset Colorectal Cancer — ACTIVE_NOT_RECRUITING
• ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer — ACTIVE_NOT_RECRUITING · PHASE2
• Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma — ACTIVE_NOT_RECRUITING · PHASE1
• Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer — ACTIVE_NOT_RECRUITING · PHASE2
• First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers — TERMINATED · PHASE1
• Advanced Endoscopic Resections for Rectal Neoplasms — NOT_YET_RECRUITING
• S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery — COMPLETED · PHASE2
• Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) — COMPLETED · NA
• Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology — NOT_YET_RECRUITING
• GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis — COMPLETED · PHASE3
• Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer — COMPLETED · PHASE2
• Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer — NOT_YET_RECRUITING · PHASE2
• Evaluation of 64Cu-ATSM PET/CT as a predictor of response to neoadjuvant therapy in locally advanced rectal cancer (TEP-64Cu-ATSM-Rectum) — OTHER · PHASE2
• Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer — COMPLETED · PHASE2
• Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting — COMPLETED · NA

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