Thalassemia Major Clinical Trials

61 clinical trials for Thalassemia Major across international registries, including 3 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Effect of Incentive Respiratory Training on Pulmonary Functions and Functional Capacity in Children With B-thalassemia Major — RECRUITING · NA
• Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia — RECRUITING · PHASE2
• Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent β-thalassemia — RECRUITING · NA
• A phase II, multicentre, clinical study evaluating the safety and efficacy of Treosulfan-based conditioning of allogenic transplantation of haemopoietic stem-cells in patients affected by Thalassemia Major — ACTIVE_NOT_RECRUITING · PHASE2
• Growth Evaluation, Health Promotion, and Clinical Management in Children and Adolescents With Thalassemia — ACTIVE_NOT_RECRUITING · NA
• Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies — COMPLETED · NA
• A Phase 2 Safety and Efficacy Study Evaluating CS-101 in Participants With β-Thalassemia Major — NOT_YET_RECRUITING · PHASE2
• A Real-World Study of β-Thalassemia Major Treatment With Luspatercept in Taiwan — ACTIVE_NOT_RECRUITING
• Study to Evaluate the Long- Term Safety and Efficacy of Luspatercept in Subjects Who Received at Least One Dose of Luspatercept in the Compassionate Use Phase — ACTIVE_NOT_RECRUITING
• EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT) — ACTIVE_NOT_RECRUITING · PHASE1
• To Evaluate Long- Term Safety and Efficacy of Luspatercept — ACTIVE_NOT_RECRUITING
• Long Term Outcomes in β Thalassemia Major — COMPLETED
• In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) — TERMINATED · PHASE1
• Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study — COMPLETED · PHASE4
• Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem Cells — SUSPENDED · NA
• Pilot Study for Patients With Poor Response to Deferasirox — COMPLETED · PHASE4
• Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem Cells — COMPLETED · NA
• Precision Exercise in Children With Malignant Hemopathies — OTHER · NA
• "Iron Overload and Endocrinological Diseases" — OTHER
• Longitudinal Study on the QoL of Pediatric Patients After HSCT and Its Influencing Factors — OTHER
• Safety and Efficacy Evaluation of Autologous CRISPR-Cas12b Edited Hematopoietic Stem Cells — OTHER · NA
• Thalassemic Iron Overload Cardiomyopathy is Ameliorated by Taurine Supplementation — OTHER · NA
• NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major — OTHER · PHASE1
• β-globin Restored Autologous HSC in β-thalassemia Major Patients — TERMINATED · PHASE1
• Prevalence of Pulmonary Hypertension (PAH) in Patients With Thalassemia — COMPLETED
• The Safety and Efficiency of Luspatercept in Chinese Adults With Transfusion Dependent β-thalassemia: a Real-world Study — OTHER · PHASE4
• Study on the Effect of Different Risk Factors on the Growth Parameters of Thalassemic Patients in Assiut (AUCH) — OTHER
• Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation — COMPLETED · PHASE2
• Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients — COMPLETED · PHASE4
• Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major — OTHER
• Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia — COMPLETED · PHASE2
• Reproductive Capacity and Iron Burden in Thalassemia — COMPLETED · NA
• Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases — COMPLETED
• Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children Hospital — COMPLETED
• The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major — COMPLETED · PHASE1
• Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI — COMPLETED · PHASE2
• Bone Marrow Transplant With Abatacept for Non-Malignant Diseases — COMPLETED · PHASE1
• Perceptions of Thalassemia Major in Singapore: An Exploratory Study of Stigma — COMPLETED
• Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis — COMPLETED · PHASE2
• A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants — COMPLETED · PHASE1
• Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion — COMPLETED · PHASE3
• Periodontal Therapy in Thalassemia Major Patients — COMPLETED · NA
• Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia. — COMPLETED · PHASE2
• Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major — OTHER · PHASE4
• An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years Old — WITHDRAWN · PHASE4
• A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload. — COMPLETED · PHASE2
• High-Tc Susceptometer to Monitor Transfusional Iron Overload — COMPLETED
• Efficacy Study in Removing Excess Iron From the Heart — COMPLETED · PHASE4
• Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia Major — OTHER · NA
• Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major — COMPLETED · PHASE2

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