Tuberous Sclerosis Complex Clinical Trials

57 clinical trials for Tuberous Sclerosis Complex across international registries, including 11 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME) — RECRUITING · PHASE1
• Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE) — RECRUITING
• A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines — RECRUITING · NA
• Treatment With Full-spectrum Cannabis Extract of Refractory Epilepsy Associated With Tuberous Sclerosis Complex (TSC) — RECRUITING · PHASE3
• Sapu003 in Advanced mTOR-sensitive Solid Tumors — RECRUITING · PHASE1
• Tuberous Sclerosis Complex and Lymphangioleiomyomatosis Pregnancy Registry (TSC-LAM Registry) — RECRUITING
• Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study — RECRUITING · PHASE2
• TANDem-2: Closing the Gap to Interventions for TAND — RECRUITING · NA
• Observational, Retrospective, Multicenter, Nonprofit Study on the Prevalence of Renal Involvement in Pediatric Patients With Tuberous Sclerosis — RECRUITING
• A MULTICENTER, OPEN-LABEL STUDY TO ASSESS THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFECT ON SEIZURES AND BEHAVIORAL SYMPTOMS OF RADIPRODIL IN PATIENTS WITH TUBEROUS SCLEROSIS COMPLEX (TSC) OR FOCAL CORTICAL DYSPLASIA (FCD) TYPE II — RECRUITING
• Placebo Controlled Study to Assess the Efficacy and Safety of Rapamycin in Drug Resistant Epilepsy Associated With Tuberous Sclerosis Complex — RECRUITING · PHASE3
• Bumetanide to treat behavioral problems in TSC — ACTIVE_NOT_RECRUITING · PHASE2
• Prospective German Real World Epidyolex® Beyond Seizure Study - PROGRESS — OTHER
• Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution — ACTIVE_NOT_RECRUITING · PHASE4
• Early Behavioral Intervention to Improve Social Communication Function in Infants With Tuberous Sclerosis Complex — COMPLETED · NA
• A Phase 2 Study of the Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy — NOT_YET_RECRUITING · PHASE2
• Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY — ACTIVE_NOT_RECRUITING
• Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment — ACTIVE_NOT_RECRUITING · PHASE3
• Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II — ACTIVE_NOT_RECRUITING · PHASE1
• Feasibility of [11C]Acetate-PET in LAM and TSC — ACTIVE_NOT_RECRUITING · PHASE1
• Precision Medicine for Neurocutaneous Syndromes in Western China — COMPLETED
• Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults — TERMINATED · PHASE1
• Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs. — COMPLETED · PHASE1
• Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy — TERMINATED · PHASE3
• Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy — COMPLETED · PHASE3
• Basimglurant (NOE-101) in Children, Adolescents, and Young Adults With TSC — COMPLETED · PHASE2
• A Phase 2B, Multicenter, 30-week, Prospective, Cross-over, Double-blind, Randomized, Placebo-controlled Study Followed by a 52-Week Open-label Extension Study to Evaluate the Efficacy and Safety of Basimglurant Adjunctive to Ongoing Anticonvulsive Therapy in Children, Adolescents, and Young Adults with Seizures Associated with Tuberous Sclerosis Complex — OTHER · PHASE2
• Predicting Epileptogenic Tubers in Patients with Tuberous Sclerosis Complex — COMPLETED
• The Effectiveness and Safety of Resective Epilepsy Surgery for TRE — ACTIVE_NOT_RECRUITING
• The Effectiveness and Safety of Vagus Nerve Stimulation for TRE — COMPLETED
• Clinical Study of NPC-12Y Gel in Patients With Skin Lesions Associated With TSC — COMPLETED · PHASE3
• Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex — COMPLETED · PHASE2
• Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants — COMPLETED · PHASE1
• Acceptance and Commitment Therapy in Tuberous Sclerosis Complex — OTHER · NA
• Efficacy and Safety of Rapamycin Versus Vigabatrin in the Prevention of Tuberous Sclerosis Complex Symptoms in Infants — OTHER · PHASE2
• Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France — OTHER
• Studies in Patients With Tuberous Sclerosis Complex — COMPLETED
• Lymphangioleiomyomatosis, a Study on Cathepsin K — COMPLETED
• A Randomized Controlled Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6) — COMPLETED · PHASE3
• An Open-label Extension Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6) — COMPLETED · PHASE3
• A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD — COMPLETED · PHASE2
• Rapalogues for Autism Phenotype in TSC: A Feasibility Study — COMPLETED · PHASE2
• Early Biomarkers of Autism in Infants With Tuberous Sclerosis Complex (TSC) — COMPLETED
• Everolimus for Cancer With TSC1 or TSC2 Mutation — COMPLETED · PHASE2
• Safety of Simvastatin in LAM and TSC — COMPLETED · PHASE1
• Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex — OTHER · PHASE2
• Dermatologic Patterns of Tuberous Sclerosis Patients and Somatic Mutation Relationship — OTHER
• Potential EEG Biomarkers and Antiepileptogenic Strategies for Epilepsy in TSC — COMPLETED
• Trial of RAD001 and Neurocognition in Tuberous Sclerosis Complex (TSC) — COMPLETED · PHASE2
• Tuberous Sclerosis Complex Natural History Study: Renal Manifestations — COMPLETED

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