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Extract
Background and study aims Infertility is when a couple cannot get pregnant (conceive), despite having regular unprotected sex. 10-15% of reproductive-aged couples trying to achieve pregnancy remain childless. Nearly half of all cases of infertility are due to male infertility. Male infertility is caused by abnormal sperm. In 45% of subfertile or infertile men the cause is unknown. This condition is called idiopathic (oligo)±(atheno)±(terato)spermia (iOAT). There are reports showing that the supplement l-carnitine alone or in combination with other micronutrients improves sperm parameters (i.e., number, movement, shape of sperm). Micronutrients, often referred to as vitamins and minerals, are parts of the diet which are required by the body in small amounts. The aim of this study is to compare the short-term effects of a combination of eight micronutrients including l-carnitine versus l-carnitine alone on sperm parameters as a treatment for iOAT. Who could participate? Infertile men aged 20-60 What did the study involve? Participants are allocated to one of two groups. Participants in group 1 are given l-carnitine twice a day for three months. Participants in group 2 are given a combination of eight micronutrients including l-carnitine once a day for three months. Each participant provides two sperm samples before and then again after the treatment period. The samples are then analysed for sperm count and mobility (how well they move). What were the possible benefits and risks of participating? Participants may benefit from improved sperm quality. No side effects are expected. Where was the study run from? Karl Landsteiner Institut für zellorientierte Therapie in der Gynäkologie (Austria) When did the study start and how long did it run? January 2004 to January 2014 Who was funding the study? Investigator initiated and funded Who is the main contact? 1. Prof. Dr Martin Imhof 2. Dr Markus Lipovac
Inclusion criteria
- Reduced reproductive capability in men presenting an unexplained (unidentified) abnormal semen analysis