Denosumab or Zoledronic acid for erosive hand osteoarthritis (EHOA) in patients with osteoporosis a randomized controlled trial (ZODIAC trial)
- Registry ID
- 2026-526828-41-00
- Source registry
- CTIS
- Status
- Authorised
- Phase
- PHASE2
- Study type
- INTERVENTIONAL
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
- Enrollment
- 150
- Last update
- 2026-08-14
Conditions
- Diseases [C] - Musculoskeletal Diseases [C05]
- Erosive hand osteoarthritis (EHOA)
Primary outcomes
The primary endpoint is the difference in mean change of total erosion volume (mm3) of target joints (II, III, IV, V distal and proximal interphalangeal joints and II, III, IV, V metacarpal phalangeal joints) assessed with high resolution peripheral quantitative computed tomography (HRpQCT) using standardized approach between baseline (V1) and 12 months after baseline (V4)
Locations
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