A PHASE 3 STUDY OF SODIUM THIOSULFATE FOR REDUCTION OF CISPLATIN-INDUCED OTOTOXICITY IN CHILDREN WITH AVERAGE-RISK MEDULLOBLASTOMA AND REDUCED THERAPY IN CHILDREN WITH MEDULLOBLASTOMA WITH LOW-RISK FEATURES

Registry ID

ACNS2031

Source registry

HEALTH_CANADA

Status

Ongoing

Phase

PHASE3

Study type

INTERVENTIONAL

Sponsor

CHILDRENS ONCOLOGY GROUP

Start date

2025-09-02

Last update

2025-07-07

Conditions

• MEDULLOBLASTOMA

Related clinical trials

• PHASE II TRIAL OF EFLORNITHINE/DFMO AS MAINTENANCE THERAPY FOR MOLECULAR HIGH RISK/VERY HIGH RISK AND RELAPSED/REFRACTORY MEDULLOBLASTOMA
• PHASE III RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF METFORMIN FOR COGNITIVE RECOVERY AND WHITE MATTER GROWTH IN PAEDIATRIC PATIENTS WITH A BRAIN TUMOUR
• A PHASE 2 STUDY OF REDUCED THERAPY FOR NEWLY DIAGNOSED AVERAGE-RISK WNT-DRIVEN MEDULLOBLASTOMA PATIENTS
• NEWLY DIAGNOSED CHILDREN (LESS THAN 10 YEARS OLD) WITH MEDULLOBLASTOMA AND OTHER CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS: CLINICAL AND MOLECULAR RISK-TAILORED INTENSIVE AND COMPRESSED INDUCTION CHEMOTHERAPY FOLLOWED BY CONSOLIDATION WITH EITHER SINGLE CYCLE (LOW RISK PATIENTS) OR RANDOMIZATION (HIGH RISK PATIENTS) TO EITHER SINGLE-CYCLE OR TO THREE TANDEM CYCLES OF MARROW-ABLATIVE CHEMOTHERAPY WITH AUTOLOGOUS HEMATOPOIETIC PROGENITOR CELL RESCUE
• A CLINICAL AND MOLECULAR RISK-DIRECTED THERAPY FOR NEWLY DIAGNOSED MEDULLOBLASTOMA

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