The primary objective of this study is to investigate the efficacy of 8-months treatment of Sandostatin LAR High Dose monotherapy or Sandostatin LAR High Dose in combination either with GH antagonist or dopamine agonist to control both biochemical parameters GH and IGF-I in a large population of acromegalic patients not achieving biochemical normalization after at least 6 months of SSA at conventional regimen. For the purpose of this study, the definition of SSA at conventional regimen is Sandostatin LAR octreotide at 30 mg every 28 days - Autogel lanreotide at 120 mg every 28 days.