Investigation of the anti-inflammatory effects of simvastatin in a model of acute lung injury after inhalation of lipopolysaccharide by healthy volunteers

Registry ID

EUCTR2006-004396-35

Source registry

EUCTR

Status

Completed

Phase

PHASE2

Sponsor

Belfast City Hospital Trust

Start date

2006-09-29

Completion date

2010-11-10

Last update

2026-08-16

Conditions

• Acute lung injury (ALI)

Summary

The hypothesis of the study is that treatment with simvastatin for 4 days will reduce pulmonary inflammation induced by LPS inhalation in humans. The primary outcome measure will be a reduction in bronchoalveolar lavage (BAL) CXCL8 concentration between the simvastatin and placebo treated groups.

Locations

• , , UK

View on source registry