Investigation of the protective effects of keratinocyte growth factor (KGF) in a human lipopolysaccharide induced model of acute lung injury

Registry ID

EUCTR2008-000441-58

Source registry

EUCTR

Status

Completed

Phase

PHASE2

Sponsor

Belfast City Hospital

Start date

2008-05-30

Completion date

2015-04-09

Last update

2026-08-16

Conditions

• Acute lung injury

Summary

The hypothesis of the study is that treatment with a clinically relevant dose of KGF reduces pulmonary and systemic inflammation induced by LPS inhalation in humans. The primary endpoint of this study is to evaluate the ability of KGF to reduce alveolar epithelial injury, as measured by BAL RAGE concentration, between the KGF and placebo treated groups.

Locations

• , , UK

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