Administration of Ketamine, an anaesthetic drug, in the perineural space vs intravenous, to reverse the peripheral and central pain sensitization in phantom limb pain, a phenomena thought to be linked with the N-methyl-D-aspartate (NMDA) receptors which are activated both in the peripheral and central nervous system and are related to the maintenance of pain.
- Registry ID
- EUCTR2010-024265-40
- Source registry
- EUCTR
- Status
- Ongoing
- Phase
- PHASE3
- Sponsor
- HOSPITAL UNIVERSITARI DE BELLVITGE
- Start date
- 2011-10-27
- Last update
- 2026-08-16
Conditions
Summary
To determine whether blocking NMDA receptors (N-methyl-D-aspartate) at peripheral perineural can reverse phantom limb pain. The molecular mechanisms of peripheral and central sensitization, necessarily involve the glutamate-NMDA system, which can be blocked by the anesthetic drug ketamine albeit at the expense of unacceptable side effects from excessive doses. His administration at low doses, but in the target organ may reduce these adverse reactions and be more effective.
Locations
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