(1) Generation of SPINK5 gene modified keratinocytes (including keratinocyte stem cells)(self-renewing cells) from patients with Netherton Syndrome (2) Generation of epithelial sheets for auto-grafting (tissue transplant from one part of the body to another in same individual) using gene corrected keratinocyte stem cells (3) Grafting of gene corrected epithelial sheets onto patients with Netherton Syndrome (4) To examine long-term safety and efficacy of the treatment