A Study to Test the Effect and Safety of Brodalumab Compared With Placebo and the Results of Stopping and Restarting Brodalumab Treatment in People with Moderate to Severe Plaque Psoriasis: AMAGINE-1

Registry ID
EUCTR2012-000651-13
Source registry
EUCTR
Status
Prematurely Ended
Phase
PHASE3
Sponsor
Amgen Inc.
Start date
2012-06-27
Completion date
2015-10-02
Last update
2026-08-16

Conditions

Summary

Compared with placebo: - To evaluate the efficacy of brodalumab (210 mg every 2 weeks [Q2W]; and 140 mg Q2W) in subjects with moderate to severe plaque psoriasis, as measured by the proportion of subjects achieving 75% improvement in Psoriasis Area and Severity Index (PASI; PASI 75) at week 12. - To evaluate the efficacy of brodalumab (210 mg Q2W; and 140 mg Q2W) in subjects with moderate to severe plaque psoriasis, as measured by the proportion of subjects achieving success (clear [0] or almost clear [1]) on the static physician’s global assessment (sPGA) at week 12

Locations

View on source registry