Controlled Human Malaria Infection model for evaluation of transmission-blocking interventions – Study 1

Registry ID

EUCTR2016-001379-66

Source registry

EUCTR

Status

Prematurely Ended

Phase

PHASE2

Sponsor

Radboud university medical center

Start date

2016-04-14

Last update

2026-08-16

Conditions

• Plasmodium falciparum malaria

Summary

- To evaluate the safety of four different CHMI-trans protocols in healthy malaria-naïve volunteers challenged with Plasmodium falciparum by sporozoite challenge. - To determine the best CHMI-trans protocol for induction of stable gametocytaemia at densities detectable by qRT-PCR

Locations

• , , Netherlands

Related clinical trials

• MAL RISK II: Risk of complications in outpatient treatment of imported Plasmodium falciparum malaria – an observational study in TropNet
• Determinants of semi-immunity and disease tolerance in malaria

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