Sodium hypochlorite formulation as an adjunct to nonsurgical periodontal treatment-a prospective randomized clinical trial
Nonsurgical periodontal treatment
Patients are randomly allocated to study or control group. Randomization is based on a computer-generated list. Patients randomized to the study group are treated non-surgically (SRP, scaling and root planing) according to the following procedure: after a periodontal examination, a preparation with NaOCl/AA (Perisolv®) is applied into the pockets with PD ≥ 5 mm. The formulation is prepared immediately before application by mixing the contents of two syringes. A gel is introduced into the pockets with PD≥5mm with a sterile applicator. The gel is left in place for 30 seconds. This is followed by a total subgingival scaling and root planing using an EMS Piezon ultrasonic scaler (EMS) with a PS tip (Perio Slim). In the control group, the SRP procedure is performed with the same instruments without Perisolv® application. Clinical examination is planned at baseline, 3 months and 6 months. Gingival crevicular fluid collection is planned 1 week, 2weeks, 3 months and 6 months.
1. Diagnosed with periodontitis stage II or III, grade B or C 2. Presence of at least 16 teeth (with at least 4 in each quadrant) 3. Presence of at least 4 deep periodontal pockets (PD ≥ 5 mm) 4. No professional hygiene procedures in the last 6 months 5. No systemic antibiotic therapy in the last 3 months 6. Age over 18 years 7. Being a non-smoker
1. General contraindications to any periodontal therapy 2. Immunosuppression or immunological incompetence 3. Uncontrolled diabetes 4. Pregnancy and breastfeeding 5. Alcohol and/or drug dependence 6. Patient requiring antibiotic cover prior to periodontal therapy 7. Patient with no opportunity to participate in the programme for 6 months