Risk of malaria in children who have reached the age of 5 years and are no longer eligible for seasonal malaria chemoprevention and or seasonal vaccination in Burkina Faso and Mali
Malaria
The study is built on a large randomised clinical trial investigating whether combining seasonal malaria chemoprevention (SMC) and seasonal vaccination is better than seasonal malaria chemoprevention and seasonal vaccination alone. This study started on January 2017 and now that children are getting older (aged more than 59 months), they are no longer eligible for SMC or seasonal vaccination. This study will procede by two methods : a) Children aged over 59 months who are no longer receiving SMC will be followed at the health facility to record their medical history and malaria episode from July 1 2021 to December 31 2024. Malaria episodes will be compared between the previous study arm to see whose group is providing more episodes of malaria, b) case control studies. One for uncomplicated malaria and the second for severe malaria. In these case control studies, children presenting at the study clinics with uncomplicated malaria or severe malaria will be recruited as cases. Two community controls will be recruited to match the cases in the uncomplicated malaria case control study while four controls (two communities and two hospital) will be recruited for one severe malaria case. Case controls studies will take place in 2021 (July-Dec 2021) and if any rebound is seen another set of case control studies will be carried out in 2022 (July-Dec).
1. Belonging to the seasonal malaria chemoprevention or seasonal vaccination cohort and aged over 59 months 2. Provision of signed informed consent
Absence of informed consent