Time to norepinephrine in sepsis – a prospective inception cohort study
Sepsis with hypotension
This is an observational study. Participants are identified at the Emergency Department (ED) based on clinical criteria (suspected sepsis and hypotension). Data is collected prospectively using a paper Case Report Form (CRF) and supplemented with data from the participants' electronic medical records (EMR). Participation involves no changes to standard clinical care; the study only monitors and records the timing of interventions and fluid volumes as they occur in real-time or as documented in the medical records during the first 24 hours of care. Study design and setting This is a prospective, multicenter cohort study involving emergency departments across Sweden. Patients will be enrolled over 28 days. Number of subjects The study aims to include approximately 204 patients who present to the emergency department in Swedish hospitals with sepsis and hypotension and where at least 61 subsequently receive NE. Expected duration of the study Each participating site will select 28 days for patient enrollment. Follow-up will continue for 90 days post-enrollment. The study is anticipated to commence on [Start Date] and conclude on [End Date]. Participants All patients presenting to the emergency department at each site with suspected sepsis and hypotension will be screened for eligibility by local investigators. Discontinuation of data collection Data collection will go on for 24 hours. Study closure The study will end after the pre-planned number of participants has been enrolled.
1. Age ≥ 18 years 2. Suspected sepsis defined as, blood cultures obtained and intravenous antibiotics administered. 3. Hypotension defined as MAP < 65 mmHg. 4. eSOFA 2 points or more
Prior enrollment in this study.