Collection of cervical cells at colposcopy using a novel technique for analysis of high-risk vs low-risk lesions

Registry ID
ISRCTN13994246
Source registry
ISRCTN
Status
No longer recruiting
Study type
INTERVENTIONAL
Sponsor
Cambridge University Hospitals NHS Foundation Trust
Enrollment
387
Start date
2017-10-12
Completion date
2026-07-31
Last update
2026-08-17

Conditions

Summary

Cervical cancer

Detailed description

The patient will be invited to take part in the study. The woman will have been informed that there is an active research programme in the colposcopy clinic. Following consent with the study nurse, the patient will discuss her case with the colposcopist. When the woman is ready for the colposcopy, a digital photograph of the cervix will be taken after the removal of the cervical mucus with a cotton bud (takes less than 10 seconds the system is set up to take colpophotographs). The filter disc is applied to the surface of the cervix for 15 seconds with mild pressure (no discomfort for the patient). The disc is removed and stored in transport medium. The standard colposcopic examination then begins with the application of an acetic acid solution. A further colpophotograph is taken. Biopsies or treatment as per the underlying disease are performed as required. Correlation between the two photographs, the colposcopist's opinion and the histology will be made with the disc. The researchers aim to recruit 2-3 patients per week and aim for a mixture of patients with referral for high-grade and low-grade abnormalities.

Interventions

Inclusion criteria

1. Participant is willing and able to give informed consent for participation in the study 2, Female, aged 25 years or above 3. Diagnosed with abnormal cervical cytology by routine screening

Exclusion criteria

1. Participant is unable to give consent 2. Pregnant 3. HIV/systemic Immunosuppression

Locations

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