The severity of periodontitis and the effects of periodontal treatment on disease activity of patients with rheumatoid arthritis as well as the influence of medication on periodontitis
Periodontitis and Rheumatoid Arthritis
After a full-mouth dental and periodontal examination, participants with periodontitis are randomized to one of two groups. Those in the first group receive conventional periodontal treatment only at the time of inclusion into the study (control group). Those in the second group undergo the periodontal treatment every three months (intervention group) for one year year. The conventional periodontal treatment includes oral hygiene instructions, supra- and subgingival scaling and root planning. Patients in need of specialist treatment (e.g. surgical periodontal treatment) are remitted to periodontal clinic. Participants are assessed for their rheumatoid arthritis activity at baseline and at the study end. Participants are also evaluated for their periodontal parameters such as probing pocket depth, clinical attachment loss, antibodies, microbial profiles and inflammatory mediators.
1. ≥18 years of age 2. Fulfilling the 2010 ACR criteria for RA 3. Moderate to severe periodontitis, defined according to the classification criteria of the CDC Working Group meant for usage in Population-Based Surveillance of Periodontitis 4. Written informed consent to participate 5. Swedish national registration number
1. Antibiotic treatment ≤3 months prior to inclusion into the study 2. Periodontal treatment (surgical or non-surgical) ≤3 months prior to inclusion into the study 3. Pregnancy 4. Simultaneous participation in other interventional studies