Influence of new implant surface decontamination method (Galvosurge®) in the surgical reconstructive treatment of peri-implant related intrabony defects
Removal of the attached biofilm and calculus from dental implant surface
Current interventions as of 06/10/2025: Surgical procedures will be performed one month after non-surgical periodontal treatment. On the same day of surgical therapy an antibiotic will be administered for 7 days (amoxicillin 500 mg/7 days/8 hours). Full thickness flap will be elevated and infected tissues will be removed. Implant surface decontamination will be performed with test (Titanium brush + Galvosurge®) or control methods (titanium brush) randomly assigned. Randomization will be performed using a Microsoft Excel®-generated randomization list, with the treatment allocation contained in sealed envelopes that will be prepared by a research assistant not involved as clinician or examiner. Both the patient and the clinician performing the surgical intervention will be masked to the group allocation until the randomization envelope will be opened intra-surgically. The examiner will be masked to the group allocation at all follow-up visits, and the patients will be asked not to reveal their treatment assignment to the examiners. The intrabony defect will be filled with Xenogain Collagen® and Xenoprotect® resorbable membrane and the flaps will be sutured to their previous position. Sutures will be removed 2 weeks after surgical therapy. Clinical examinations will be performed at 4, 12, 24 and 48 weeks after surgical therapy. Maintenance therapy will be realized at 12, 24 and 48 weeks after therapy. Previous interventions: Surgical procedures will be performed one month after non-surgical periodontal treatment. On the same day of surgical therapy an antibiotic will be administered for 7 days (amoxicillin 500mg/7 days/8 hours). Full thickness flap will be elevated and infected tissues will be removed. Implant surface decontamination will be performed with test (Galvosurge®) or control methods (titanium brush) randomly assigned. Randomization will be performed using a Microsoft Excel®-generated randomization list, with the treatment allocation contained in sealed e
1. Age ≥ 18 years 2. Peri-implant bone defect ≥3 mm assessed radiographically 3. Peri-implant pocket depth (PPD) ≥5 mm combined with bleeding on probing or suppuration 4. Intra-surgically, bone defect must have at least an intraosseous component of 3 mm and a width of no more than 4mm 5. Implants ≥1 year in function
1. Treated for peri-implantitis during the previous 6 months 2. Intake of systemic or local antibiotics during the previous 6 months 3. Pregnant patients 4. Systemically unhealthy patients 5. Patients allergic to collagen