Tongue-preserving treatment using brachytherapy and intensity-modulated radiation therapy technique for localized tongue cancer

Hybrid brachytherapy followed by intensity-modulated radiation therapy (HyBIRT) technique for the definitive management of localized tongue cancer

Registry ID

ISRCTN18070464

Source registry

ISRCTN

Status

Recruiting

Study type

INTERVENTIONAL

Sponsor

Universiti Sains Malaysia

Enrollment

100

Start date

2021-10-11

Completion date

2030-12-10

Last update

2026-08-17

Conditions

• Cancer

Summary

Tongue squamous cell cancer (TSCC)

Detailed description

The HyBIRT technique involves: 1. Upfront interstitial brachytherapy to tongue tumor 20 Gy in 5F 2. Adoptive intensity modulated radiation therapy (IMRT) to the tongue and neck (56.1 Gy - 69.96 Gy in 33F with dose painting method) with concurrent weekly cisplatin chemotherapy

Interventions

• OTHER: The HyBIRT technique involves: 1. Upfront interstitial brachytherapy to tongue tumor 20 Gy in 5F 2. Adoptive intensity modulated radiation therapy (IMRT) to the tongue and neck (56.1 Gy - 69.96 Gy in 33F with dose painting method) with concurrent weekly cisplatin chemotherapy

Inclusion criteria

1. Patients with histology-confirmed TSCC 2. Tumor limited to anterior 2/3 (mobile tongue), TNM7 stage T1-4a, N1-2c, M0 3. Refused surgery or unfit for surgery 4. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2

Exclusion criteria

1. Tumor involving the posterior third of the tongue 2. Radiologically confirmed metastatic disease (M1) 3. Contraindication for nasal intubation 4. ECOG Performance Status 3-4

Locations

• , , Malaysia

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