A UK study of minimally invasive emergency treatment of sudden bleeding from the lower bowel

A multi-centre retrospective observational study investigating outcomes after emergency transcatheter arterial embolisation for acute non-variceal lower GI bleeding

Registry ID
ISRCTN18144604
Source registry
ISRCTN
Status
Recruiting
Study type
OBSERVATIONAL
Sponsor
University Hospitals Plymouth NHS Trust
Enrollment
800
Start date
2026-02-01
Completion date
2028-10-01
Last update
2026-08-17

Conditions

Summary

Patients who have undergone angiography +/- embolisation for acute non-variceal lower GI haemorrhage.

Detailed description

Data will be collected by a named doctor as part of the IR trainee research collaborative (UNITE) or interventional radiology trainees, junior doctors and medical students at each participating centre and will be maintained on an anonymised (REDCap) database. They will be supervised by an Interventional Radiology Consultant who will be a permanent employee of that centre. This type of work is part of their expected role for the purposes of quality improvement and revalidation. Registrars will collect this data as part of their training time where there is a requirement to be involved in audit and research. Applicants from participating sites can register to be an Associate PI for this study as part of the NIHR Associate Principal Investigator Scheme. All data will be anonymised prior to leaving the centre. All data will be collected using the purpose-built electronic database Research Electronic Data Capture (REDCap) platform, which is overseen by the University of Plymouth. No identifiable data (patient number, full name, date of birth) will be recorded or shared. Data collected falls into the following categories (examples given after each category are not exhaustive ): ● Participant ID number (pseudo-anonymised) ● Demographics: Age, gender, date of admission ● Comorbidities ● Pre-procedural imaging: Dates, modalities, diagnosis ● Treatments offered prior to procedure: Antibiotics, IV fluids, blood transfusion, endoscopy ● Procedure: Date, procedural findings ● Intraoperative complications ● Post-operative complications: Types, date of occurrence, treatment ● Follow up: readmissions, 30-day mortality, cause of death, further interventions The patients will not be contacted at any point. At no point will the data be identifiable outside the site at which embolisation was performed. Only anonymised data will be sent to the central research team for analysis. Data will be collected, analysed and held on secure Trust PC and on the purpose-built electronic database

Interventions

Inclusion criteria

1. Adult patients (aged 16 years or more) undergoing emergency embolisation for acute non-variceal lower GI bleeding 2. Date of procedure from 01/01/2023 to 01/06/2025

Exclusion criteria

1. Patients who underwent embolisation for variceal GI bleeding 2. Patients who underwent embolisation for upper GI bleeding 3. Patients who underwent embolisation for chronic gastrointestinal bleeding (defined as >30 days)

Locations

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