Dynamic diaphragm function trajectory via ultrasound predicts weaning outcomes in mechanically ventilated patients: the diaphragm-protective ventilation (DMV) study
Dynamically monitor diaphragmatic function in mechanically ventilated patients in the intensive care unit (ICU) using point-of-care ultrasound, explore its trajectory, and evaluate its predictive value for weaning outcomes.
This is a prospective cohort study to dynamically assess diaphragmatic function using bedside ultrasound to predict weaning outcomes in mechanically ventilated patients. During the study, researchers will perform ultrasound examinations every other day to monitor indicators such as your diaphragmatic thickness, diaphragmatic thickening fraction, and diaphragmatic mobility.
1. Age ≥ 18 years old 2. Intubated orally or nasotracheal with invasive mechanical ventilation 3. Expected duration of mechanical ventilation > 48 hours 4. Informed consent was obtained from their legal representatives of patients
1. Previous known diaphragmatic disease or paralysis (e.g., cervical spinal cord injury, amyotrophic lateral sclerosis, etc.) 2. Previous history of thoracic surgery, especially involving the diaphragm or lung resection, may severely affect diaphragmatic anatomy 3. Use of neuromuscular blocking agents 4. History of chronic obstructive pulmonary disease 5. Pregnant women 6. Technical difficulties in surface ultrasound examination (e.g., severe subcutaneous emphysema, extreme obesity) 7. Other conditions considered by the investigator to be inappropriate for inclusion (e.g., terminal state, treatment withdrawal).