A randomised multiple centre trial of conservative versus liberal fluid administration for children receiving a kidney transplant
Fluid management in paediatric kidney transplantation
Summary of treatment in each group: - Intervention: Fluid volume administration capped at maximum 150ml/m²/hour for no longer than 18 hours following transplant, reduced to a fixed daily target of maximum 1.5 litres/m²/day thereafter. No specific urine output will be targeted. No diuretics to be administered throughout. - Comparator: Target urine output >2ml/kg/hour. Fluid administered to replace urine output + insensible losses for at least 48 hours. Diuretics per the clinical team’s usual practice. Follow up period: Follow up data up will be collected up to 3 months post-transplant. Randomisation: Eligible patients who have consented to participate in LIMITS will be randomised via an interactive web response system, provided by Sealed Envelope. Participants will be randomised in a 1:1 ratio, to the intervention and comparator groups. The randomisation will be stratified by transplant centre and donor type (deceased vs. living donation). Randomisation will further be balanced within blocks of varying, undisclosed sizes.
1. Children under 18 years of age at the time of transplantation with valid informed consent 2. Children receiving a kidney only transplant from either a living or deceased donor, in a participating UK centre
Multi-organ transplant recipients