Specialised pro-RESOLVing lipid mediators in the resolution of acute Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD)
This is an observational study. The aim of this study is to investigate the effects of an acute exacerbation of COPD on resolution physiology. This study is divided into a main study and a sub-study. The population is patients admitted to hospital with an acute exacerbation of COPD. As part of the main study, the surplus of the blood sample taken on admission to hospital will be analysed and participants will be given the option to donate a spontaneous sputum sample. Participants in the sub-study must already be enrolled in the main study to participate. Participants will donate a blood sample daily from the day of consent until the day they are discharged from the hospital. They will be invited to return for a follow-up visit 3-months post hospitalisation where a 'recovery' sample will be collected.
1. Participant is willing and able to give informed consent for participation in the study 2. Male or Female, aged 18 years old and above 3. Able (in the Investigator's opinion) and willing to comply with all the study requirements 4. Hospitalised following an acute exacerbation
1. Female participants who are pregnant or lactating 2. Participant is unwilling or unable to give informed consent for participation 3. Unable (in the Investigators opinion) or unwilling to comply with the study requirements 4. Participants who are unable to understand written and spoken English. 5. Participant has any other significant disease or disorder which, in the opinion of the Investigator may either put the participants at risk, influence their ability to participate in the study or influence the result of the study. This includes but is not limited to - respiratory diseases such as asthma, bronchiectasis, pneumonia and cancer. 6. Patients that require intubation or admission to ICU.