Zhongshan High Myopia Cohort: the natural history of myopic maculopathy and optic neuropathy in individuals with high myopia
Individuals with high myopia
Current interventions as of 12/03/2024: The ZHMC study is a retrospective and prospective ambispective cohort study that includes individuals who completed the 8-year follow-up from Zhongshan Ophthalmic Centre–Brien Holden Vision Institute (ZOC-BHVI) High Myopia Cohort Study and newly recruited subjects with high myopia. All individuals with high myopia in the study will be followed up every 2 years over a continuous period of 8 years. The examinations include: questionnaire surveys (e.g. basic demographic information, general medical history), general physical examinations (e.g. height, weight), and ocular examinations (strabismus and dominant eye, visual acuity, visual field, intraocular pressure, refraction, slit lamp examination, anterior segment photography, ocular biometry , (ultra-widefield) optical coherence tomography (OCT), ultra-widefield OCT angiography (OCTA), (ultra-widefield) fundus photography and autofluorescence, fundus examination, and magnetic resonance imaging (a portion of our participants by random sampling). _____ Previous interventions: The ZHMC study is a retrospective and prospective ambispective cohort study that includes individuals from Guangzhou, China. All individuals with high myopia in the study will be followed up every 2 years over a continuous period of 8 years. The examinations include: questionnaire surveys (e.g. basic demographic information, general medical history), general physical examinations (e.g. height, weight), and ocular examinations (strabismus and dominant eye, visual acuity, visual field, intraocular pressure, refraction, slit lamp examination, anterior segment photography, ocular biometry , (ultra-widefield) optical coherence tomography (OCT), ultra-widefield OCT angiography (OCTA), (ultra-widefield) fundus photography and autofluorescence, fundus examination, and magnetic resonance imaging (a portion of our participants by random sampling).
1. Sphere ≤ −6.00 diopter (cylinder is not included) in both eyes 2. Aged between 7 and 70 years old
1. Secondary myopia, such as a history of retinopathy of prematurity or neonatal problems, or syndromic myopia with a known genetic disease or connective tissue disorders, such as Stickler or Marfan syndrome 2. History of laser treatment for myopia correction or any intraocular surgery affecting refractive status 3. Have autoimmunity disease such as systemic lupus erythematosus, rheumatoid arthritis; 4. Have severe health problems precluding follow-up such as end-stage heart disease, kidney disease, lung disease, or terminal cancer 5. Have significant ocular media opacity preventing fundus examinations (e.g.dense corneal opacity) 6. Unable to give their own informed consent 7. Plan to move from the area within the next 8 years