Acute effect of breaking up sitting on peripheral and cerebral blood flow in adults with type 1 diabetes using closed-loop systems insulin systems
Improvement of vascular health in people with type 1 diabetes.
The study will use a randomised, crossover design, in which participants will complete two 7-hour experimental conditions, each separated by at least 4 days. One condition will involve participants sitting uninterrupted for 7 hours (sedentary), while the other will involve participants breaking up 7 hours of sitting with 3 minutes of low-intensity walking every 30 minutes (active breaks). The order of the two trials will be randomised and counterbalanced using a computer-generated random allocation sequence (www.randomization.com). Due to the nature of the study, blinding of the participants or researchers is not possible. However, participants and researchers will be blinded to experimental condition order (by keeping the order in a sealed envelope) until 07:00 on the morning of the first experimental visit.
1. Having been diagnosed with T1D for more than 3 years 2. Aged 18-66 years 3. Not currently meeting physical activity guidelines of > 150 min/week of moderate-intensity exercise or >75 min/week of high-intensity exercise 4. Are sedentary (normally spend more than 5h per day sitting or lying down) 5. Use a closed-loop insulin delivery system
1. Pregnant or planning to become pregnant 2. <6 months postpartum or stopped breastfeeding <1 month before recruitment 3. Having been diagnosed with cerebrovascular or cardiovascular disease 4. Having a significant history of uncontrolled hyperglycaemia (HbA1c >85 mmol/L) 5. Having a history of severe hypoglycaemia requiring third-party assistance within the last 3 months 6. Cold or flu within the last 2 weeks