Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective Study

Registry ID
NCT07762573
Source registry
NCT
Status
RECRUITING
Study type
OBSERVATIONAL
Sponsor
Nanfang Hospital, Southern Medical University
Enrollment
2500
Start date
2026-08-03
Completion date
2030-01-30
Last update
2026-08-13

Conditions

Summary

To evaluate the utility of DCR-derived parameters for identifying dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of disease progression in COPD.

Detailed description

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Approximately 100 million people in China have COPD, yet the early diagnosis rate remains below 13%. This multicenter retrospective study will collect previously acquired dynamic chest radiography (DCR) images, pulmonary function test results, chest computed tomography images, symptom scores, clinical data, and follow-up outcomes from participating centers. A standardized multicenter retrospective DCR-COPD database will be established to systematically evaluate the utility of DCR-derived parameters for characterizing dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of COPD progression. The study will also provide a foundation for model development and subsequent prospective multicenter validation.

Inclusion criteria

Inclusion Criteria: 1. Aged 30-85 years. 2. Male or female. 3. Patients who underwent pulmonary function testing and dynamic chest radiography at the hospital.

Exclusion criteria

Exclusion Criteria: 1. Incomplete medical records. 2. Considered unsuitable for inclusion in the study at the investigator's discretion.

Primary outcomes

[{"measure":"Exacerbation/respiratory history and event","timeFrame":"At Baseline"},{"measure":"FEV1 %","timeFrame":"At Baseline"},{"measure":"FEV1 /FVC","timeFrame":"At Baseline"},{"measure":"Emphysema","timeFrame":"At Baseline"},{"measure":"diaphragm movement","timeFrame":"At Baseline"},{"measure":"lung field area","timeFrame":"At Baseline"},{"measure":"lung field area change rate","timeFrame":"At Baseline"},{"measure":"CAT","timeFrame":"At Baseline"},{"measure":"SGRQ","timeFrame":"At Baseline"},{"measure":"mMRC","timeFrame":"At Baseline"},{"measure":"Smoking history and status","timeFrame":"At Baseline"}]

Locations

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