Progression, Management, and Clinical Outcomes of Coronary Artery Aneurysms

Progression, Management Strategies, and Risk Factors of Coronary Artery Aneurysms: A Multicenter, Retrospective Cohort Study

Registry ID

NCT07764081

Source registry

NCT

Status

RECRUITING

Study type

OBSERVATIONAL

Sponsor

Nanjing First Hospital, Nanjing Medical University

Enrollment

1000

Start date

2026-07-31

Completion date

2028-08-30

Last update

2026-08-13

Conditions

• Coronary Artery Disease
• Aneurysms
• Coronary Intervention

Summary

This study aimed to characterize the progression and risk fators of coronary artery aneurysms, and copmpare the outcomes across different management strategies

Detailed description

This study aim to investigated the progression of coronary artery aneurysms (CAA) assessed by angiography, then compared the effectiveness of different management strategies, and identified risk factors associated with lesion progression and major adverse cardiovascular events.

Inclusion criteria

Inclusion Criteria: 1. Angiographically confirmed coronary artery aneurysm, defined as coronary dilation ≥1.5 times the adjacent normal reference vessel diameter. 2. Age 18-80 years.

Exclusion criteria

Exclusion Criteria: 1. Suboptimal image quality 2. Incomplete clinical data, including medical history, laboratory parameters, or follow-up records.

Primary outcomes

[{"measure":"Progression of coronary artery aneurysm","timeFrame":"6-12 months"}]

Locations

• Nanjing First Hospital, Nanjing, China

Publications

• Nunez-Gil IJ, Cerrato E, Bollati M, Nombela-Franco L, Terol B, Alfonso-Rodriguez E, Camacho Freire SJ, Villablanca PA, Amat Santos IJ, de la Torre Hernandez JM, Pascual I, Liebetrau C, Camacho B, Pavani M, Albistur J, Latini RA, Varbella F, Jimenez-Diaz VA, Piraino D, Mancone M, Alfonso F, Linares JA, Rodriguez-Olivares R, Jimenez Mazuecos JM, Palazuelos Molinero J, Sanchez-Grande Flecha A, Gomez-Hospital JA, Ielasi A, Lozano I, Omede P, Bagur R, Ugo F, Medda M, Louka BF, Kala P, Escaned J, Bautista D, Feltes G, Salinas P, Alkhouli M, Macaya C, Fernandez-Ortiz A; CAAR investigators. Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR). Int J Cardiol. 2020 Jan 15;299:49-55. doi: 10.1016/j.ijcard.2019.05.067. Epub 2019 Jul 19.

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