Mefloquine Prophylaxis in HIV-1 Individuals: a Randomized Placebo-controlled Trial This is a randomized placebo controlled trial. Malaria chemoprophylaxis with mefloquine in asymptomatic HIV-infected adults living in a malaria endemic region of Luanshya, Zambia will be c...

• Pays Zambia
• Organes Aucun
• Spécialités Aucune

Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries The purpose of this study is to examine effective methods of preventing the transmission of HIV from mother to child during pregnancy, labor and delivery, and breastfeeding. This is one pa...

• Pays India, Malawi, South Africa, Tanzania, United Republic of, Uganda, Zambia, Zimbabwe
• Organes Aucun
• Spécialités Aucune

An international multicentre controlled clinical trial to evaluate high dose RIFApentine and a QUINolone in the treatment of pulmonary tuberculosis http://www.ctu.mrc.ac.uk/research_areas/study_details.aspx?s=49

• Pays Botswana, Mozambique, South Africa, Zambia, Zimbabwe
• Organes Aucun
• Spécialités Aucune

Simplified Severe Sepsis Protocol in Zambia This study is a randomized control trial assessing the impact of a simple evidence-based protocol for the treatment severe sepsis in Zambia. The intervention protocol consists of a schedul...

• Pays Zambia
• Organes Aucun
• Spécialités Aucune

Immune Reconstitution to Measles Virus of HIV Infected Children in Zambia This is an observational study of HIV-1 infected children starting antiretroviral therapy to measure the magnitude and quality of general immune reconstitution and pathogen-specific immune...

• Pays Zambia
• Organes Aucun
• Spécialités Aucune

First Breath: Neonatal Resuscitation in Developing Countries In developing countries, neonatal death from birth asphyxia is a major problem. This study will be conducted in several countries to determine if the combined Neonatal Resuscitation Progra...

• Pays Argentina, Congo, Guatemala, India, Pakistan, Zambia
• Organes Aucun
• Spécialités Aucune

Trial of the Use of Antenatal Corticosteroids in Developing Countries Multi-country two-arm, parallel cluster randomized controlled trial to reduce neonatal mortality through increasing the rate of antenatal corticosteroid administration to eligible women.

• Pays Argentina, Guatemala, India, Kenya, Pakistan, Zambia
• Organes Aucun
• Spécialités Aucune

Non-virologic Methods to Diagnose Treatment Eligibility in HIV-exposed Infants This study is designed to develop and evaluate a set of non-virologic diagnostic algorithms to monitor HIV-exposed children of unknown infection status for treatment eligibility during the...

• Pays Zambia
• Organes Aucun
• Spécialités Aucune

Maternal TDF and FTC to Reduce NNRTI Resistance Mutations After Intrapartum NVP The purpose of this study is to determine whether the addition of tenofovir (TDF) and emtricitabine (FTC)to a standard PMTCT regimen containing single-dose nevirapine (NVP) can reduce the ...

• Pays Zambia
• Organes Aucun
• Spécialités Aucune

An evaluation of the impact of early initiation of Highly Active Anti-Retroviral Therapy (HAART) on Tuberculosis (TB) treatment outcomes for TB patients co-infected with Human Immunodeficiency Virus (HIV) Not provided at time of registration

• Pays South Africa, Tanzania, United Republic of, Uganda, Zambia
• Organes Aucun
• Spécialités Aucune